Vanderbilt University

Venostent, Inc.

Timothy C Boire

Colleen M Brophy

Mukesh Kumar Gupta

Hak-Joon Sung

Angela L Zachman

Sue Hyun-Lee

Colin Dodson

Nick Sears

Laura Rose Emerson

Bryan Khai Ngo

Geoffrey A Lucks

Sue Hyun Lee

Natacha Rodrigues

Steven M Tallman, Jr

The present invention relates generally to shape memory polymer devices that are porous. The porosity of the device may generate advantageous neovascularization, decrease inflammation, and decrease fibrosis. The device may include a surface having a pore size of 400 μm-1200 μm and a pore spacing of about 100 μm to about 750 μm.

Polymeric vascular grafts which induce neovascularization with mild to minimal inflammation and promotion of fibrovascular tissue

In one aspect of the present disclosure, devices and methods of treating a vascular anastomosis is disclosed. In one embodiment, the method comprises the steps of: (a) determining the outer diameter of a first vessel to be surgically coupled to a second vessel creating a vascular anastomosis; (b) determining the outer diameter of the second vessel; (c) selecting a perivascular wrap from a plurality of differently sized perivascular wraps such that the perivascular wrap fits around the vascular anastomosis with a constriction of the first vessel of less than 30%; wherein the perivascular wrap includes a shape memory polymer and has at least a first end, a second end, and a medial region; (d) positioning the perivascular wrap onto the first vessel via the first end prior to construction of the vascular anastomosis; (e) coupling the first vessel and the second vessel constructing the vascular anastomosis; and (f) molding the perivascular wrap from a first shape to a second shape wherein the second shape conforms to the geometry of the vascular anastomosis such that the perivascular wrap provides artery-mimetic support to the vascular anastomosis in the range of 0.1-2.0 MPa.

Synthetic perivascular wrap

The presently-disclosed subject matter includes a compound comprising a first monomer, which is allyl-functionalized and crosslinkable, and a second monomer, which is not crosslinkable. In some embodiments the compounds are photocrosslinkable, and in certain embodiments are photocrosslinkable by ultraviolet light. Also provided are shape memory vascular grafts comprised the of present compounds that can transition from a temporary shape to an original shape when heated above a melting temperature of the graft. Still further provided are methods for treating vascular conditions that utilize embodiments of the present grafts.

Shape memory polymers and methods of use

The present invention relates generally to shape memory polymer devices that are porous. The porosity of the device may generate advantageous neovascularization, decrease inflammation, and decrease fibrosis. The device may include a surface having a pore size of 500-750 microns and a pore spacing of 220-250 microns.

Growing community of inventors

Nashville, TN, United States of America

Timothy C Boire