Visiongate, Inc.

Other

Timothy Bell

Michael G Meyer

Alan C Nelson

Daniel J Sussman

Rahul Katdare

Laimonas Kelbauskas

Jonus Reyna

Chris Presley

Frances Ginn Howard

A method for enhancing gating performance of a cell sorter to prepare an enriched specimen for optical tomography cell analysis includes introducing a specimen into a FACS to generate 2D event data; generating a first scatterplot of the 2D data; identifying target objects; constructing a boundary within the first scatterplot to produce a first gate; counting target objects within the first gate; comparing the number of target objects within the first gate to a first predetermined value and adjusting the first gate as necessary. A boundary around a set of target objects is constructed in a second scatterplot to produce a subset second gate and target objects within the second gate are counted and the count compared to a second predetermined value. When a boundary around target objects meets specifications the first and second gates are stored in memory and used to enrich patient specimens.

Specimen enrichment for optical tomography cell analysis

A method for a system and method for morphometric detection of malignancy associated change (MAC) is disclosed including the acts of obtaining a sample; imaging cells to produce 3D cell images for each cell; measuring a plurality of different structural biosignatures for each cell from its 3D cell image to produce feature data; analyzing the feature data by first using cancer case status as ground truth to supervise development of a classifier to test the degree to which the features discriminate between cells from normal or cancer patients; using the analyzed feature data to develop classifiers including, a first classifier to discriminate normal squamous cells from normal and cancer patients, a second classifier to discriminate normal macrophages from normal and cancer patients, and a third classifier to discriminate normal bronchial columnar cells from normal and cancer patients.

Morphometric detection of malignancy associated change

A cytological analysis test for 3D cell classification from a specimen. The method includes isolating and preserving a cell from the specimen and enriching the cell before embedding the enriched cell into an optical medium. The embedded cell is injected into a capillary tube where pressure is applied until the cell appears in a field of view of a pseudo-projection viewing subsystem to acquire a pseudo-projection image. The capillary tube rotates about a tube axis to provide a set of pseudo-projection images for each embedded cell which are reconstructed to produce a set of 3D cell reconstructions. Reference cells are classified and enumerated and a second cell classifier detects target cells. An adequacy classifier compares the number of reference cells against a threshold value of enumerated reference cells to determine specimen adequacy.

System and method for determining cell adequacy in a cytological analysis system

A combination pipe cutter and can lid opener comprising a means for cutting and a means for opening a can having a lid. The combination pipe cutter and can lid opener comprises two handles, one having a holder to hold a pipe and the other having a blade, wherein the blade is utilized to cut the pipe in the holder. The insides of the handles comprise semicircular openings having gripping teeth for opening the lid of a container. To open the lid of the container, the semicircular cutouts of the first handle and second handle are positioned around the perimeter of the lid, wherein the gripping teeth cooperatively engage the lid thereby opening the container by turning the combination pipe cutter and can lid opener.

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Phoenix, AZ, United States of America

Timothy Bell