The Procter Gamble Company

Timothy Bates

John McMillan McIver

Todd Laurence Underiner

Donald Carroll Roe

Robb Richard Gardner

John August Wos

Hiroshi Oh

Scott Edward Osborne

Francis James Rourke

A cleaning composition may comprise a pH-switchable sudsing system and a cleansing system. The pH-switchable sudsing system may comprise a primary sudsing agent in combination with a pH-switchable co-surfactant. The pH-switchable co-surfactant is selected from diamine molecules having a general formula RR&#x2014;N&#x2014;R&#x2014;N(CH)X, where Ris a linear or branched Cto Chydrocarbyl, Ris a linear or branched Cto Chydrocarbyl, Ris a linear or branched Cto Chydrocarbylene, and X is a counteranion. The tertiary amine nitrogen of the pH-switchable co-surfactant has a pKvalue. When the tertiary amine nitrogen is unprotonated, the pH-switchable co-surfactant may provide a suds-boosting effect in washing solutions at a washing pH above the pK. When the tertiary amine nitrogen is protonated, the pH-switchable co-surfactant may provide a suds-reducing benefit in rinse waters at a rinse pH below the pK.

Cleaning compositions comprising pH-switchable amine surfactants

The invention provides an absorbent article, at least a portion of which has a protease inhibitor incorporated therein to decrease the activity of proteases that may otherwise initiate or contribute to inflammation of the skin of a wearer of the article resulting in skin irritation or dermatitis. The article can further comprise a delivery system for releasably containing and delivering the protease inhibitor to at least a portion of the skin of the wearer. The delivery system can comprise a skin care composition and at least a portion of the composition, including the protease inhibitor, is automatically transferred from the article to the wearer's skin without manual intervention during normal usage of the article to form a defense against protease activity. Most preferably, repeated application of similarly treated articles to the wearer's skin provides an available source from which the protease inhibitor continuously transfers onto the skin over time and accumulates to provide a proactive defense against protease activity for the reduction or prevention of skin irritation or dermatitis due to proteolytic enzymes.

Protease inhibitors in absorbent articles

Enzyme Inhibitors

The present invention relates to compounds, compositions, and methods which are useful for the prevention and treatment of adverse health, skin, hair, and oral conditions. The compounds, compositions, and methods are also widely applicable for use in health, skin, hair, oral, beauty, and personal care applications. In particular, the present invention relates to compounds having the structure: ##STR1## and the tautomers, acceptable salts, and biohydrolyzable amides, esters, and imides thereof, wherein A, Q, n, P, L.sub.1, L.sub.2, L.sub.3, L.sub.4, Z, X, B.sub.1, and B.sub.2 are defined herein.

Enzyme inhibitors

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Cincinnati, OH, United States of America

Timothy Bates