The General Hospital Corporation

Timothy Antonie Berendsen

Mehmet Toner

Martin L Yarmush

Mustafa Korkut Uygun

Maria-Louisa Izamis

Robert Marius Bieganski

Osman Berk Usta

Basak Elif Uygun

Sinem Perk

The present invention generally relates to methods and compositions to determine viability of an organ for transplantation and other medical purposes. One aspect of the invention relates to a method for assessing the viability of an organ by measuring the energy parameters to determine the energy level of the organ by determining the stored cellular energy (e.g., ATP levels), and/or energy consumption over a particular time period of viability. The energy parameters can be compared to reference energy parameters as a highly accurate and reliable prediction of viable cell yield, and organ viability. Another aspect of the invention relates methods to preserve or extend the time period of viability of an organ any combination of (i) preservation perfusion of the organ to prevent ischemic damage, (ii) chemical metabolic suppression of the organ e.g., using metabolic suppressants, (iii) metabolic suppression by physical or environmental conditions, e.g., sub-zero non-freezing storage.

Methods and compositions for preserving tissues and organs

Growing community of inventors

Melrose, MA, United States of America

Timothy Antonie Berendsen