Genta Incorporated

Timothy Andrew Riley

Mark A Reynolds

David Aaron Schwartz

Lyle J Arnold, Jr

Robert E Klem

Richard I Hogrefe

Morteza M Vaghefi

Bob Dale Brown

Lloyd Robert Snyder

William B Marvin

Restraining device

Oligomers having chirally pure phosphonate internucleosidyl linkages mixed with non-phosphonate internucleosidyl linkages which hybridize to RNA target sequences and methods for their preparation are provided.

Synthetic oligomers having chirally pure phosphonate internucleosidyl

Oligomers having phosphonate internucleosidyl linkages which are enriched for phosphonate linkages of a preselected chirality which hybridize to an RNA target sequence and methods for their preparation are provided.

Chirally enriched synthetic phosphate oligomers

Chirally enriched synthetic phosphonate oligomers

Methods for purifying an oligomer by normal phase column chromatography on a support selected from polyhydroxyethyl aspartamide, hydrophilic silica and silica from an oligomer impurity having a different nucleoside sequence are described. These methods are based upon the different retention times of the oligomer and the impurity on the column.

Process for the purification of oligomers

Synthetic oligomers having chirally pure phoshonate internucleosidyl

Methods of synthesizing oligomers using low water oxidizer reagents which result in high coupling efficiencies are provided. These methods are suitable for larger scale preparations of methylphosphonate oligomers.

Process for the synthesis of oligonucleotides and analogs with low water

Polymeric reagents useful in the solid phase synthesis of oligomers are provided. These polymeric reagents are suitably loaded with nucleosidyl moieties and do not undergo non-specific chain elongation.

Growing community of inventors

Nipomo, CA, United States of America

Timothy Andrew Riley