University of Illinois

Leland Stanford Junior University

Timothy Alan Garrow

Gary A Peltz

Guochun Liao

Hong-Hsing Liu

The present disclosure relates generally to a pharmaceutical compositions and methods of reducing acetaminophen-induced liver toxicity. The disclosure includes pharmaceutical compositions including acetaminophen and one or more components selected from S-adenosylhomocysteine (SAH), S-methylmethionine (SMM), or a pharmaceutically acceptable salt thereof. The disclosure also relates to methods of reducing acetaminophen-induced liver toxicity in a subject by administering or co-administering one or more of S-adenosylhomocysteine (SAH), S-methylmethionine (SMM), or a pharmaceutically acceptable salt thereof, with acetaminophen to a subject.

Compositions and methods for reducing the risk of agent-induced liver toxicity

The present invention provides a method of decreasing total plasma homocyst(e)ine levels in an animal in need of such treatment, comprising the step of administering to said animal a pharmacologically effective dose of a thetin. Further provided is a method of treating hyperhomocyst(e)inemia in an animal in need of such treatment, comprising the step of administering to said animal a pharmacologically effective dose of a thetin. Also provided are novel pharmaceutical and nutritional compositions. Further provided is a method of reducing or eliminating the costly supplementation of methionine, choline, and betaine to protein-containing animal feeds.

Growing community of inventors

Mahomet, IL, United States of America

Timothy Alan Garrow