Bone Care International, Inc.

Other

The United States of America As Represented by the Secretary of

United States of America, As Represented by the Secretary of Agriculture

Horst, Ronald L.

Koszewski, Nicholas J.

Reinhardt, Timothy A.

Timothy A Reinhardt

Robert M Moriarty

Charles W Bishop

Joyce C Knutson

Raju A Penmasta

Liang Guo

Glenville Jones

Stephen Strugnell

Lei Zhao

Ronald L Horst

Nicholas J Koszewski

Sanjay K Singhal

John D Lippolis

Sanjay K Singh-Al

Hydroxylated derivatives of vitamin D3 (cholecalciferol) and vitamin D2 (ergocalciferol) are effective for preventing or treating mastitis in animals. The hydroxylated derivatives of vitamins D3 or D2 are administered to the mammary gland of a female animal in an amount effective to inhibit or significantly reduce the growth of bacteria in the animal's mammary gland.

Use of vitamin D in dairy mastitis treatment

1&agr;,24(S)-Dihydroxy vitamin D,which is useful as an active compound of pharmaceutical compositions for the treatment of disorders of calcium metabolism and for various skin disorders. The invention also includes preparation of synthetic 1&agr;,24(S)-dihydroxy vitamin D,starting from ergosterol which is converted in six steps to 24-hydroxyergosterol. 24-Hydroxyergosterol is irradiated and thermally converted to 24-hydroxy vitamin D,which is converted in six steps to 1&agr;,24(S)-dihydroxy vitamin D,. The syntheses also produced novel intermediates.

Methods for preparation and use of 1&agr;,24(S)-dihydroxy vitamin D2

Methods for preparation and use of 1&agr;,24 (S)-dihydroxy vitamin D2

1.alpha.,24(S)-Dihydroxy vitamin D.sub.2 which is useful as an active compound of pharmaceutical compositions for the treatment of disorders of calcium metabolism and for various skin disorders. The invention also includes preparation of synthetic 1.alpha.,24(S)-dihydroxy vitamin D.sub.2 starting from ergosterol which is converted in six steps to 24-hydroxyergosterol. 24-Hydroxyergosterol is irradiated and thermally converted to 24-hydroxy vitamin D.sub.2 which is converted in six steps to 1.alpha.,24(S)-dihydroxy vitamin D.sub.2. The syntheses also produced novel intermediates.

Methods for preparation and use of 1.alpha., 24(S) -dihydroxy vitamin D2

Methods for preparation and use of 1A,24(S)-dihydroxy vitamin D2

Methods for preparation and use of 1.alpha.,24(S)-dihydroxy vitamin D.sub.2

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Ames, IA, United States of America

Timothy A Reinhardt