Monsanto Company

Monsanto Technology LLC

Calgene Corporation

Apt Therapeutics, Inc.

Renessen LLC

Rapp, William

Slater, Steven

Liang, Jihong

Jeong, Soon Seog

Weaver, Lisa M.

Chen, Ridong

Mitsky, Timothy

Timothy A Mitsky

Ganesh M Kishore

David M Stark

Steven C Slater

Stephen Rogers Padgette

Ridong Chen

Soon Seog Jeong

Michael W Lassner

James D Weiss

Martha Ann Post-Beittenmiller

Jawed Asrar

Beth Savidge

Nilgun E Tumer

Ming Hao

Devang T Shah

Cynthia Lou Hemenway

Kenneth Gruys

Kenneth James Gruys

Steven Charles Slater

Lisa M Weaver

Steven Slater

Balasulojini Karunanandaa

Henry E Valentin

Jihong Liang

Lisa Marie Weaver

William D Rapp

Qungang Qi

Edgar Clifford Lawson

Thomas E Clemente

Kathryn L Houmiel

Steven E Reiser

The present invention provides for design and therapeutic use of ADPase enhanced polypeptides, pharmaceutical compositions, and methods useful for preventing and reversing platelet aggregation and recruitment for the treatment and prevention of vascular disorders in mammals.

Therapeutic use of ADPase enhanced apyrases

Design and therapeutic use of adpase enhanced apyrases

Nucleic acid sequences and methods are provided for producing plants and seeds having altered tocopherol content and compositions. The methods find particular use in increasing the tocopherol levels in plants, and in providing desirable tocopherol compositions in a host plant cell.

Nucleic acid sequences to proteins involved in tocopherol synthesis

The present invention provides soluble forms of CD39L3 polypeptides and compositions, and methods useful inhibiting platelet activation and recruitment for the treatment and prevention of thrombotic disorders in mammals administered with soluble forms of CD39L3 polypeptides.

Therapeutic use of soluble CD39L3

The present invention is in the field of plant genetics and biochemistry. More specifically, the invention relates to genes associated with the tocopherol biosynthesis pathway. The present invention provides and includes nucleic acid molecules, proteins, and antibodies associated with the genes of the tocopherol biosynthesis pathway. The present invention also provides methods for utilizing such agents, for example in gene isolation, gene analysis and the production of transgenic plants. Moreover, the present invention includes transgenic plants modified to express proteins associated with the tocopherol pathway. In addition, the present invention includes methods for the production of products from the tocopherol biosynthesis pathway.

TyrA genes and uses thereof

The present invention provides transgenic plants transformed with an isolated DNA encoding a monomeric anthranilate synthase. The present invention also provides an isolated DNA encoding a monomeric anthranilate synthase from. Transformation vectors and transformed plants containing the isolated DNA and seeds derived therefrom, are also provided.

Transgenic high tryptophan plants

Nucleic acid sequences, vectors, recombinant host cells, transgenic plants, and methods for their preparation are disclosed. The nucleic acid sequences encode threonine deaminase proteins that catalyze the conversion of threonine to &#x3b1;-ketobutyrate. One or both of the amino acids at positions 447 and 481 of the encoded proteins can be selected from groups of particular amino acids. For example, the amino acid at position 447 can be alanine, isoleucine, valine, phenylalanine, tryptophan, or methionine. The amino acid at position 481 can be alanine, isoleucine, proline, phenylalanine, tryptophan, or methionine.

Modified threonine deaminase

Nucleic acid encoding a modified threonine deaminase and methods of use

Nucleic acid sequences to proteins involved in isoprenoid synthesis

The use of multigene vectors for the preparation of transformed host cells and plants is disclosed. Multigene vectors reduce the number of transformations required, and leads to increased production of polyhydroxyalkanoate polymer in the resulting transformed host cells and plants.

Multigene expression vectors for the biosynthesis of products via multienzyme biological pathways

Methods for the biosynthesis of polyhydroxyalkanoate homopolymers and copolymers are described. In a preferred embodiment, the polymers have a single mode molecular weight distribution, and more preferably have a distribution of between about 2 and about 4, and most preferably about 2.1 or 2.5.

Polyhydroxyalkanoates of narrow molecular weight distribution prepared in transgenic plants

Polyhydroxyalkanoates of narrow molecular weight distribution prepared

An isolated DNA sequence which codes for a luteo replicase gene is disclosed herein. A method for providing resistance to infection by a virus by expressing a replicase gene in plants is also disclosed, as are transgenic plants containing the replicase gene.

Plants resistant to infection by luteoviruses

Genes and methods for optimizing levels of substrates employed in the biosynthesis of copolymers of 3-hydroxybutyrate (3HB) and 3-hydroxyvalerate (3HV) in plants and bacteria via manipulation of normal metabolic pathways using recombinant DNA techniques are provided. This is achieved through the use of a variety of wild-type and/or deregulated enzymes involved in the biosynthesis of aspartate family amino acids, and wild-type or deregulated forms of enzymes, such as threonine deaminase, involved in the conversion of threonine to P(3HB-co-3HV) copolymer endproduct. By these methods, enhanced levels of threonine, .alpha.-ketobutyrate, propionate, propionyl-CoA, .beta.-ketovaleryl-CoA, and .beta.-hydroxyvaleryl-CoA are produced. Also provided are methods for the biological production of P(3HB-co-3HV) copolymers in plants and bacteria utilizing propionyl-CoA produced through a variety of engineered metabolic pathways. Introduction into plants and bacteria of an appropriate .beta.-ketothiolase, .beta.-ketoacyl-CoA reductase, and PHA synthase, alone or in combination with various enzymes involved in asparate family amino acid biosynthesis and the conversion of threonine to PHA copolymer precursors, will permit these organisms to produce P(3HB-co-3HV) copolymers.

Methods of optimizing substrate pools and biosynthesis of

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Maryland Heights, MO, United States of America

Timothy A Mitsky