Memorial Sloan Kettering Cancer Center

Other

Icahn School of Medicine at Mount Sinai

The Simons Center for Systems Biology at the Institute for Advanced Study

Laessig, Michael

Timothy A Chan

Naiyer A Rizvi

Matthew D Hellmann

Taha Merghoub

Jedd David Wolchok

Arnold J Levine

Nadeem Riaz

Diego Chowell Puente

Robert M Samstein

Luc Morris

Michael Laessig

Steven D Leach

Marta Luksza

Vinod P Balachandran

Benjamin D Greenbaum

Molecular determinants of cancer response to immunotherapy are described, as are systems and tools for identifying and/or characterizing cancers likely to respond to immunotherapy.

Determinants of cancer response to immunotherapy by pd-1 blockade

Systems and methods for determining the likely responsiveness of a human cancer subject to a checkpoint blockade immunotherapy regimen are provided. Sequencing reads are obtained from samples from the subject representative of the cancer. A human leukocyte antigen type and a plurality of clones is determined from the sequencing reads. For each clone, an initial frequency Xin the one or more samples is determined and a corresponding clone fitness score of the clone is computed, thereby computing clone fitness scores. Each such fitness score is computed by identifying neoantigens in the respective clone, computing a recognition potential for each neoantigen, and determining the corresponding clone fitness score of the respective clone as an aggregate of these recognition potentials. A total fitness, quantifying the likely responsiveness of the subject to the regimen, is computed by summing the clone fitness scores across the plurality of clones.

Neoantigens and uses thereof for treating cancer

Determinants of cancer response to immunotherapy

The present invention encompasses the discovery that the likelihood of a favorable response to cancer immunotherapy for a wide range of different cancers can be predicted through definition of a tumor mutational load threshold for the tumor (and/or the relevant immunotherapy).

Tumor mutational load

Determinants of cancer response to immunotherapy by PD-1 blockade

The present invention is directed to a glove system comprising a plurality of closed tip finger sheath with a secondary finger sheath disposed near the finger tips to allow for improved interaction with a portable electronic devices.

Glove for use with touch interface devices

A method and system for attaching LEDs to circuitry which would protect the LEDs from heat damage and allows for individual LEDs to be removed.

Method and system for attachment of light emitting diodes to circuitry for use in lighting

Growing community of inventors

New York, NY, United States of America

Timothy A Chan