Tengion, Inc.

Inregen

Regenmedtx, LLC

Prokidney

Timothy A Bertram

Manuel J Jayo

Oluwatoyin A Knight

Roger M Ilagan

Andrew T Bruce

Deepak Jain

John W Ludlow

Richard Payne

Namrata D Sangha

Sharon C Presnell

Russell W Kelley

Shay M Wallace

Sumana Choudhury

Eric S Werdin

H Scott Rapoport

Kelly Guthrie

Joydeep Basu

Christopher W Genheimer

Darell McCoy

Patricia D Tatsumi

Jessica J Reinsch

Craig R Halberstadt

Elias A Rivera

Benjamin Watts

Thomas Spencer

Neil F Robins

Bryan R Cox

Sarah F Quinlan

Darrell Mccoy

Teresa B Burnette

Jacob E Shokes

Sarah A Boyd

Dominic M Justewicz

Wendy Sharp

Scott H Rapoport

Russel W Kelley

The present invention concerns methods of using bioactive renal cell populations to provide regenerative effects to a native kidney for the treatment of chronic kidney disease.

Bioactive renal cells for the treatment of chronic kidney disease

The present invention concerns bioactive renal cells populations, renal cell constructs, and methods of making and using the same.

Bioactive renal cells

The invention is directed to isolated renal cells, including tubular and erythropoietin (EPO)-producing kidney cell populations, and methods of isolating and culturing the same, as well as methods of treating a subject in need with the cell populations.

Isolated renal cells and uses thereof

The present invention concerns bioactive renal cell populations, renal cell constructs, and methods of making and using the same.

The present invention relates to the regeneration, reconstruction, repair, augmentation or replacement of organs or tissue structures using scaffolds and autologous cells that are not derived from such organs or tissues.

Cell scaffold constructs

Biocompatible synthetic or natural scaffolds are provided for the reconstruction, repair, augmentation or replacement of organs or tissue structures in a patient in need of such treatment. The scaffolds are shaped to conform to at least a part of the organ or tissue structure and may be seeded with one or more cell populations. Inserts, receptacles and ports are also provided for the attachment of tubular vessels to the neo-organ scaffolds. The seeded scaffolds are implanted into the patient at the site in need of treatment to form an organized organ or tissue structure. The scaffolds may be used to form organs or tissues, such as bladders, urethras, valves, and blood vessels.

Scaffolds for organ reconstruction and augmentation

Cell-scaffold constructs

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Winston-Salem, NC, United States of America

Timothy A Bertram