Aventis Pharmaceuticals Inc.

Sanofi

Hoechst Marion Roussel

Timothy A Ayers

Richard A Schnettler

John G Jurcak

Harald Berchtold

Norbert Nagel

Bruno Baumgartner

George Lee

Paul Wayne Brown

Gilbert Marciniak

Damian J Krysan

Paul W Brown

The invention relates to a benzoic acid salt of methyl(2R,3R)-2-{3-[amino(imino)methyl]benzyl}-3-{[4-(1-oxidopyridin-4-yl)benzoyl]amino}butanoate, and to a benzoic acid salt of methyl(2R,3R)-2-{3-[amino(imino)methyl]benzyl}-3-{[4-(1-oxidopyridin-4-yl)benzoyl]amino}butanoate which is in a crystalline form or in at least partially crystalline form, as well as a process for the preparation of the same, methods of using such salt to treat subjects suffering from conditions which can be ameliorated by the administration of an inhibitor of Factor Xa.

Benzoic acid salt of otamixaban

The compounds are of the class of thienoisoxazole phenoxy unsubstituted ethyl and propyl derivatives, useful as Dantagonists. Said compounds are useful for the treatment of medical conditions mediated by inhibition of Dreceptor. These conditions comprise, for example, Attention Deficit Hyperactivity Disorder, Obsessive-Compulsive Disorder, Psychoses, Substance Abuse, Substance Dependence, Parkinson's Disease, Parkinsonism, Tardive Diskinesia, Gilles de la Tourette Syndrome, Conduct Disorder, and Oppositional Defiant Disorder. A further aspect of the invention is to provide a pharmaceutical composition, intermediates, and a method of making said class of compounds.

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This invention relates to a process for the preparation of compounds of the formula:wherein Ris C-Calkyl and the C-Calkyl moiety is straight or branched.

Antihistaminic piperidine derivatives and intermediates for the preparation thereof

This invention relates to a novel process for preparing 2,3-dihydro-benzofuranol derivatives and to the novel intermediates produced thereby.

Process for preparing 2,3-dihydro-benzofuranol derivatives

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Loveland, OH, United States of America

Timothy A Ayers