Koninklijke Philips Corporation N.V.

Timo Paulus

Bernd Schweizer

Lothar Spies

Alexander Fischer

Ralph Brinks

Jens-Christoph Georgi

Dragos-Nicolae Peligrad

Ana Belen Martin Recuero

The invention relates to a general composite compartmental model and a compartmental analysis procedure to extract non-invasively the concentration (C) of the imaging agent in plasma (), in metabolites () and in blood elements () (like red cells, platelets, plasma protein etc.) from time signal curves measured within a reference tissue region (). This is made possible by deploying an injection function (S(t)) as input which models the amount of imaging agent administered to the patient as a function of time. The invention allows the presentation of the plasma input function to the medical practitioner without the need for invasively drawing blood samples.

System for the noninvasive determination of tracer concentration in blood

A radiological imaging method comprises: acquiring radiological lines of response (LOR's) from a subject; grouping the acquired LOR's into time intervals such that each group of LOR's () was acquired during a selected time interval; identifying a region of interest () for each time interval based on LOR's grouped into that time interval; for each time interval, determining a positional characteristic () of the region of interest identified for that time interval based on LOR's grouped into that time interval; for each time interval, spatially adjusting LOR's grouped into that time interval based on the positional characteristic of the region of interest identified for that time interval; and reconstructing at least the spatially adjusted LOR's to generate a motion compensated reconstructed image.

Radiological imaging incorporating local motion monitoring, correction, and assessment

Growing community of inventors

Aachen, Germany

Timo Paulus