Other

Roche Diabetes Care, Inc.

Roche Diagnostics Gmbh

F. Hoffmann-la Roche Ag

Timo Ottenstein

Wolfgang Petrich

Christian Ringemann

Markus Plum

Carina Horn

Bernd Limburg

Markus Serr

Simon Aigner

Gabriele Chemnitius

Andreas Meyer

Methods are provided for deriving/determining an analyte concentration that include recording measurement values during a time development indicating a progress of a detection reaction of at least one test substance and a body fluid sample and providing at least one measurement curve F(t) containing the measurement values, where the detection reaction is known to be influenced by the analyte concentration and at least one disturbance variable Y. The methods also include deriving an end value of the measurement curve to form a first variable x, and deriving at least one fit parameter by taking into account an exponential characteristic of the measurement curve, and where the fit parameter forms at least one second variable x. The methods further include deriving/determining the analyte concentration by using at least one multivariate evaluation algorithm adapted to combine xand x. Also provided are computer programs and devices that incorporate the same.

Methods of determining an analyte concentration in a body fluid sample having disturbance variables, as well as computer programs and devices therefor

Methods are provided for detecting an analyte concentration/presence in a body fluid sample that include providing a set of at least two different evaluation rules, each evaluation rule adapted to derive a set characteristic values from an optical measurement curve, where at least one first characteristic value is derived from at least one first evaluation rule and at least one second characteristic value is derived from at least one second evaluation rule. The methods also include performing at least one multivariate analysis of the at least one first and second characteristic values by using at least one predetermined multivariate evaluation algorithm to derive at least one estimate value for at least one target variable Y of the state variables. The methods also include determining at least one analyte concentration by using the at least one target variable Y. Also provided are computer programs and devices that incorporate the same.

Methods of evaluating medical measurement curves, as well as computer programs and devices therefor

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Heidelberg, Germany

Timo Ottenstein