Other

Labmaster Oy

Labmaster Ltd.

Oy Elflot Ltd

Leiras Oy

Oy Alko Ab

Biotecnol S.a.

Conventa Ltd.

Santen Pharmaceutical Co., Ltd.

Atabekov, Joseph

Karpova, Olga

Ivanov, Peter

Korpela, Timo

Dorokhov, Yurii

Rodionova, Nina

Timo Korpela

Sakari Kulmala

Jarkko Uolevi Eskola

Timo Ala-Kleme

Yurii Dorokhov

Joseph Atabekov

Maxim Vladimirovich Skulachev

Alexander Lashkul

Olga Karpova

Peter Ivanov

Nina Rodionova

Teppo Tapani Laaksonen

Radii Khomutov

Vladimir Zav'yalov

Natalia Battchikova

Choong-Kyang Kang

Anton Zavialov

Philip Canty

Piia Vainio

Simo Laakso

Tatiana Zargarova

Ksenia Kromina

Alexei Khomutov

Dmitry Yakovlev

Timo Väinö Kalevi Ala-Kleme

Olga Shulga

Elena Navalotskaya

Daria Shumilina

Vladimir Zavialov

Mikhail Pridanniko

Maria Kouznetsova

Piia Kaarina Mäkinen

Sheila Macintyre-Ayane

Lada Petrovskaya

Galina Petrovna Korobko

Sergey Morozov

Natalia Batchikova

Vitali Djavakhia

Vitaly Dzhavakhia

Mauri Makela

Juhani Lundell

Johanna Suomi

Alexei Filippov

Elena Ivanovna Dudich

Oleg Nikolaev

Lidia Nikolaevna Semenkova

Anja Kopio

Konstantin Skryabin

Igor Vyacheslavovitch Dudich

Matti Ankelo

Edvward Borisovitch Tatulov

Markus Hakansson

Tatiana Voinova

Dimitry Lvovicth Zubov

Petri Perälä

Maxim Skulachev

Tony Wahlroos

Saara Korpela

A method and device is provided for combining various forms of flotation techniques to achieve a very high degree of purification of waste water while energy consumption is maintained low.

Combiflotation for purification and disinfection of waste water

The invention provides a device to purify waste water by a two-step procedure containing an electroflotation unit and an electrical disinfection unit integrated into the same overall construction. Characteristic to the construction is that the said two units have a common anode and two individual cathodes which can be in different potentials in respect to the common anode.

Construction of devices for purification and disinfection of waste water with electrical current

The invention describes simple and reliable cartridge constructions for carrying out analytical procedures in a closed system, especially for carrying out bioaffinity analyses. The cartridge exploits a measuring component, or a test strip (in FIG.) and its cover (in FIG.) as well as the motion between these two components to achieve liquid flow and events which are necessary for the analysis.

Mechanical washing and measuring device for performing analyses

Electrochemiluminescent technique and device suitable for cheap analytical and diagnostic applications, with electrodes manufactured from carbon paste and terbium chelates as labeling compounds.

Integrated carbon electrode chips for the electric excitation of lanthanide chelates, and analytical methods using these chips

The invention describes novel chemiluminescence electrode devices and their novel properties to enable achieving luminescence signal by electrical excitation by cathodic or bipolar pulses in aqueous electrolyte solutions. These devices form a significant improvement in construction of cheap and reliable means for especially diagnosis of health conditions in point-of-need purposes.

Methods and devices to generate luminescence from integrated electrode chips by cathodic and bipolar pulses

A conductor/insulator/porous film device is provided which is used in electrochemiluminescence methods and instrumentation based on the chemical excitation of label molecules with subsequent measurement of the luminescence in order to quantitate analyte concentrations especially in bioaffinity assays.

Conductor/insulator/porous film-device and its use with the electrochemiluminescence-based analytical methods

The invention relates to isolated DNA sequences encoding MF3 polypeptides that induce multiple resistance in plants toward a variety of viral and microbial infections and against pests and a method of obtaining transgenic plants expressing MF3 polypeptides. The invention also relates to a method of isolating and purifying an MF3 polypeptide from bacterial cells expressing the polypeptide and its use as a plant protectant with or without carrier agent.

Isolated DNA sequences and polypeptides inducing multiple resistance of plants to phytopathogens and pests

The present invention provides antimicrobials for efficient therapy of infections caused by bacterial pathogens. The antimicrobials include peptides corresponding to the active site of N-terminal extension of subunits composing specific adhesive organelles of virulence of pathogenic bacteria. These antimicrobial peptides inhibit surface expression of adhesive organelles and thus prevent development of infections caused by pathogenic bacteria. The invention describes also effective methods for screening molecules inhibiting the generation of the adhesive organelles.

Antimicrobials against pathogenic bacteria and method for screening them

Methods and insulator electrode devices for performing electrochemical reactions are disclosed. The devices consist of high specific surface area electrodes based on a channeled conducting base material that has been coated with an organic or inorganic insulating film or multiple layers of such films. The chemical reactions are exemplified by exciting one or several label compounds into an excited state which is spontaneously de-excited by emission of ultraviolet, visible or infrared light, in aqueous solution. This provides the basis for reproducible analytical applications in bioaffinity assays such as immunoassays and DNA-probing assays.

Insulator electrode devices

The present invention provides structures of small molecules capable of modulating apoptotic cell death. More specifically, the structures relate to the structures of apoptotic active sites of mammalian alpha-fetoprotein (AFP) and albumin. Peptides mimicking the active site contain two sequences, Arg-Gly-Asp and Asp-X-X-Asp, wherein X means any amino acid. These sequences are needed in the same molecule for causing a wide range of biological activities. The peptides can be utilized to suppress apoptotic pathways by inhibiting the cytochrome c-mediated caspase activation. Thus, the peptides can be used to inhibit effects of apoptosis induced by oxidative stress, drugs, cytokines, Fas-ligand, alpha-fetoprotein, used to prevent apoptosis in culturing cells, in organ transplantation, in immunological autoimmune disorders and immunodeficiency syndrome induced by viral infection, or to diminish side cytotoxic effects after chemotherapy and radiation therapy.

Peptides modulating caspase activation

The present invention is related to novel bioactive pentapeptides, pentarphins, the main indication of which is enhancing phagocytic activity of macrophages against microbes. In particular, the cyclopentapeptide, cyclo(Val-Lys-Gly-Phe-Tyr), termed cyclopeptarphin, was 100 times more active than tuftsin. Cyclopentarphin was non-toxic even at concentrations 1000 times higher than the minimum active dose, while being non-immunogenic. Furthermore, cyclopentarphin is more stable to enzymatic cleavage in vitro as compared to linear pentarphin and tuftsin and, hence, its life span in vivo is also larger than that of linear peptides. High efficacy and safety of cyclopentarphin enable elaboration of novel drugs that enhance the resistance of human and animal organisms to microbes and micro particles.

Peptides for enhancing resistance to microbial infections

The present invention is directed to novel aminooxy-cyclodextrin derivatives of the formula (1): CD&#x2014;(X&#x2014;Y&#x2014;ONH), wherein CD is mono- or polydeoxy &#x3b1;-, &#x3b2;-, or &#x3b3;-cyclodextrin, carrying in its 6-, 3- and/or 2-position a group containing the aminooxy group, and optionally carrying substituents different from (X&#x2014;Y&#x2014;ONH). Y is a linker group between the aminooxy group and the mono- or polydeoxy-CD group, X is a functional group or an atom necessary to connect the linker Y and the deoxy CD group, or Y is a direct bond when X is a direct bond, and n is &#x2267;1, but &#x2266;24, 21 and 18 for &#x3b1;-, &#x3b2;- or &#x3b3;-cyclodextrin, respectively, the protected aminooxy derivatives thereof, as well the methods for their preparation and use.

Derivatives of cyclodextrins

A primary object of this invention is to provide a method which will enable to coexpress simultaneously two (or more) desired genes in plant, animal or yeast cells, in transgenic plants and animals, or in vitro, in plant cell-derived or animal cell-derived translation systems. This objection is to be accomplished by utilizing sequence elements derived from RNAs of a tobamovirus upstream of MP gene or CP gene termed here as IRESand IRES, respectively. The method of this invention involves the construction of a recombinant nucleic acid sequence which comprises a specific transcriptional promoter, a first gene expressible in eukaryotic cells linked to said transcriptional promoter, IRESor IRESlocated 3' to the first gene and a second gene expressible in eukaryotic cells, located 3&#x2032; to IRES sequence such that the second gene is placed under the transcriptional control of IRES sequence originated from tobamovirus genome. The primary chimeric RNA transcript in positive sense polarity is produced by the transformed cells from the said promoter. The expression of the first gene occurs by direct translation whereas the translation of the 5&#x2032;-distal gene(s) of bicistronic (or polycistronic) mRNA will be promoted by IRESor IRES.

Methods for coexpression of more than one gene in eukaryotic cells

The present invention provides bacterial strains for secretion of soluble biologically active recombinant heterologous proteins into periplasm or on a surface/into a cultivation medium of bacteria. The invention exploits the secretion system of Gram-negative bacteria including periplasmic chaperones and usher/secretin proteins. For accomplishing the aim, the bacterial strains simultaneously express the fusion protein (signal peptide)-(mature hecterologous protein)-(subunit of a bacterial surface structure, Caf1), periplasmic chaperone specific for the subunit, and outer membrane usher/secretin protein specific for the subunit. Secretion of fusion proteins: (signal peptide of Caf1)-(mature human IL-1&#x3b2;)-(mature Caf1), (signal peptide of Caf1)-(mature human GM-CSF)-(mature Caf1), and (signal peptide of Caf1)-(mature human IL-1ra)-(mature Caf1) that were expressed insimultaneously with the periplasmic chaperone Caf1M and the usher/secretin protein Caf1A are examples of the use of the invention.

Microbial protein expression system

Growing community of inventors

Turku, Finland

Timo Korpela