Google Inc.

Timo Kohlberger

Martin Christian Stumpe

Krishna Kumar Gadepalli

Lily Peng

Yun Liu

A method is described for generating a prediction of a disease classification error for a magnified, digital microscope slide image of a tissue sample. The image is composed of a multitude of patches or tiles of pixel image data. An out-of-focus degree per patch is computed using a machine learning out-of-focus classifier. Data representing expected disease classifier error statistics of a machine learning disease classifier for a plurality of out-of-focus degrees is retrieved. A mapping of the expected disease classifier error statistics to each of the patches of the digital microscope slide image based on the computed out-of-focus degree per patch is computed, thereby generating a disease classifier error prediction for each of the patches. The disease classifier error predictions thus generated are aggregated over all of the patches.

Focus-weighted, machine learning disease classifier error prediction for microscope slide images

A method, system and machine for assisting a pathologist in identifying the presence of tumor cells in lymph node tissue is disclosed. The digital image of lymph node tissue at a first magnification (e.g., 40&#xd7;) is subdivided into a multitude of rectangular 'patches.' A likelihood of malignancy score is then determined for each of the patches. The score is obtained by analyzing pixel data from the patch (e.g., pixel data centered on and including the patch) using a computer system programmed as an ensemble of deep neural network pattern recognizers, each operating on different magnification levels of the patch. A representation or 'heatmap' of the slide is generated. Each of the patches is assigned a color or grayscale value in accordance with (1) the likelihood of malignancy score assigned to the patch by the combined outputs of the ensemble of deep neural network pattern recognizers and (2) a code which assigns distinct colors (or grayscale values) to different values of likelihood of malignancy scores assigned to the patches.

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Mountain View, CA, United States of America

Timo Kohlberger