Wallac Oy

Hidex Oy

Rados Technology Oy

Turun Yliopisto

Timo E Oikari

Tapio Yrjonen

Kauko Lehtinen

Kenneth C Rundt

Ville Haaslahti

Jarmo Nurmi

Tero Soukka

Tuula Stark

Risto Juvonen

Eveliina Arponen

Heikki K Kouru

Colin G Potter

Juhani Aalto

Petri Aronkytö

Stefan Jarnstrom

Jukka Kahilainen

Jari Suontausta

Gerald Warner

Stuart Webb

Jukka Haaslahti

The present invention provides a method for determining a background count rate in liquid scintillation counting. The method comprises measuring external standard spectra of a sample, determining, from the external standard spectra, a triple to double coincidence ratio and a quench parameter, determining, based on the triple to double coincidence ratio and the quench parameter, a background reference parameter, and determining, based on the background reference parameter, the background count rate from a background reference curve.

Method for determining a background count rate in liquid scintillation counting

The present invention provides a method for determining a background count rate in liquid scintillation counting. The method comprises measuring an external standard spectrum () of a sample, determining, from the external standard spectrum, an external standard count rate within an energy window (), determining, based on the external standard count rate within the energy window, a background reference parameter, and determining, based on the background reference parameter, the background count rate from a background reference curve ().

A method to correct measurement error in a resonance energy-transfer assay, including exciting anti-Stokes photoluminescent donors with at least one wavelength of light which is greater than an emission wavelength of acceptor molecules; measuring emission at the acceptor's emission wavelength and which differs from the donor's emission wavelength in at least two different time windows; a first time window within the time window defined by the excitation light pulse and a second non-overlapping time window which follows the first time window; and correcting the emission signal, which includes signals originating from non-radiative and radiative energy transfer, within the first time window by estimating the ratio of the signals from non-radiative and radiative energy transfer or the signal originating from radiative energy transfer using at least one emission signal measured in the second time window.

Correction method and measurement device for anti-stokes photoluminescence measurement

A homogenous bioassay including a first group including an acceptor which is a short lifetime fluorescent compound capable of energy transfer, and a second group including a quencher which is capable of energy transfer from an acceptor. The increase or decrease of the acceptor's fluorescence resulting from lengthening or shortening of the distance between the acceptor and quencher is measured. The bioassay also includes a third group including a donor for energy transfer to the acceptor, which donor is an up-conversion fluorescent compound, a long-lifetime fluorescent compound or an electrogenerated luminescent compound. The first group includes a tag, the third group includes a binder having a high affinity for binding to the tag. Fluorescence of the acceptor is brought about by exciting the donor resulting in energy being transferred from the donor to the acceptor.

Homogeneous luminescence bioassay

Photodetector involving a MOSFET having a floating gate

A gain stabilization system for photomultiplier tubes using a pulsed light source, preferably a light emitting diode (LED), the signal of which is detected at the cathode and at the anode. The gain of photomultiplier tube is stabilized by keeping the ratio between the two signals constant.

Photomultiplier having gain stabilization means

A method and a liquid scintillation counter for measuring a sample, a mixture of the specimen to be analysed and a scintillator, in a liquid scintillation counter where the sample (14) is measured with two photo multiplier tubes (23, 24) situated on different sides of the sample. The photo multiplier tubes situated on different sides of the sample operate in coincidence. Asymmetric samples are measured in such a way that the counting efficiency is measured with the photo multiplier tubes (23, 24) operating in coincidence ad calculated using the amount of coincidence pulses, whereas the amplitude and the pulse height distribution are measured only with one photo multiplier tube (23 or 24).

Method for measuring samples with liquid scintillation counting and a

An invention for preventing optical crosstalk in a process of counting liquid scintillation samples deposited in a sample plate, the sample plate composed of a plurality of sample wells, the optical crosstalk being caused by mutual optical affection between samples deposited in the sample wells. Sample wells are provided with tubes made of material impermeable but reflective or scattering for scintillation light generated by the samples.

Method and a device for preventing optical crosstalk between liquid

Method for scintillation counting and a scintillation counter with

A method for correcting measuring values when measuring liquid scintillation samples deposited on sample plates by a photodetector which will be affected by scintillation photons from other samples in the plate in addition to the sample being measured. Said correction is done by pre-determining affection of the other samples of the plate as a function of quench level and correcting observed measuring values using this information.

Method for measuring liquid scintillation samples deposited on

An arrangement for counting liquid scintillation samples on a sample plate in a liquid scintillation counter having at least one photomultiplier tube. The sample plate contains a plurality of open-bottomed wells sealed with at least one filtration membrane impregnated with a solid meltable scintillator. The arrangement includes a sample plate holder for holding and transporting the sample plate in the liquid scintillation counter. The holder includes a device to hold sample plates of different sizes and a device to enable transportation of the sample plate in the liquid scintillation counter.

Arrangement for counting liquid scintillation samples on multi-well

Method for the simultaneous assay of ligands

Detection material for ionizing radiation

A method for correcting measuring values when measuring liquid scintillation samples deposited on sample plates by a photodetector which will be affected by scintillation photons from other samples in the plate in addition to the sample being measured. Said correction is done by pre-determining affection of the other samples of the plate as a function of quench level and correcting observed measuring values using this function.

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Turku, Finland

Timo E Oikari