B.r.a.h.m.s Gmbh

Tim Ziera

Joachim Struck

Anne Incamps

Maryann Stephanie Vogelsang

Bryan Krastins

Andre Schoenichen

Ingo Curdt

Manne Krop

Frauke Dreyer

Pierre-Emmanuel Charles

André SCHÖNICHEN

The present invention relates to method for detecting a free histone protein in a biological sample of a subject, e.g. using an immunoassay or a mass spectrometric assay. It also pertains to a method for the diagnosis, prognosis, risk assessment, risk stratification and/or therapy control of a disease or medical condition, comprising detecting a free histone protein or peptide fragment thereof in a biological sample of a subject, wherein the presence of said free histone protein or fragment thereof is indicative for said disease or medical condition.

Free histone proteins as biomarkers

The present invention relates to an immunoassay method for the detection of augurin or a precursor or fragment thereof comprising contacting a sample suspected of comprising augurin or a precursor or fragment thereof with a first and second antibody specific for augurin or a precursor or fragment thereof, wherein said first and second antibodies or antigen-binding fragments or derivatives thereof are specific for epitopes comprised in the sequence spanning amino acids 71 to 107 of pre-augurin according to SEQ ID NO:1.

Augurin immunoassay

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Berlin, Germany

Tim Ziera