Abbott Laboratories Corporation

Tim Van Biesen

Kevin J Lynch

Edward C Burgard

Edward B Touma

Wende Niforatos

Randy E Metzger

Human P2X,and P2X,purinergic receptor polypeptides are provided. Nucleic acid molecules encoding the aforementioned human P2X receptor polypeptide, and vectors and host cells containing such nucleic acid molecules, are also provided. In addition, methods are provided for producing these P2X receptor polypeptide, as are methods of using such polypeptides and host cells that express the same to screen for compounds having activity on P2X,and P2X,receptors. Further, therapeutic uses involving aspects of these receptors are contemplated.

Nucleic acids encoding a functional human purinoreceptor P2X2 and P2X4, and methods of production and use thereof

Human P,X,and P,X,purinergic receptor polypeptides are provided. Nucleic acid molecules encoding the aforementioned human P,X receptor polypeptide, and vectors and host cells containing such nucleic acid molecules, are also provided. In addition, methods are provided for producing these P,X receptor polypeptide, as are methods of using such polypeptides and host cells that express the same to screen for compounds having activity on P,X,and P,X,receptors. Further, therapeutic uses involving aspects of these receptors are contemplated.

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Chicago, IL, United States of America

Tim Van Biesen