Ortho-Nutra, LLC

Klz Holdings, LLC

Tim N Ziegenfuss

Hector L Lopez

Shawn Wells

Bruce W Kneller

Matthew Titlow

An enhanced caffeinated beverage composition includes a caffeinated drink combined with an effective blend of methylliberine and theacrine providing increased mood, energy, alertness, focus, motivation, and/or decreased fatigue without adversely affecting heart rate or blood pressure.

Enhanced caffeinated beverage composition

A human dietary supplement comprises theacrine and optionally other compounds that modulate the effects of theacrine. Uses for the theacrine-containing supplement include improvement of at least one of mood, energy, focus, concentration or sexual desire or a reduction of at least one of anxiety or fatigue. A synergistic composition comprises co-administration of theacrine and caffeine, wherein the co-administered caffeine reduces theacrine oral clearance (CL/F) and oral volume of distribution (Vd/F). In addition, the co-administered caffeine increases area under the plasma concentration time curve (AUC) of theacrine, and increases theacrine maximum plasma concentration (C) in comparison with the corresponding pharmacokinetic parameters when theacrine is administered alone.

Theacrine-based supplement and method of use thereof in a synergistic combination with caffeine

Compositions and methods include a synergistically effective combination of glycerol andextract for increasing muscle volume in response to an exercise stimulus of the corresponding muscle or muscle region.

Compositions and methods for increase in muscle volume

A human dietary supplement comprises theacrine and optionally other compounds that modulate the effects of theacrine. Uses for the theacrine-containing supplement include improvement of at least one of mood, energy, focus, concentration or sexual desire or a reduction of at least one of anxiety or fatigue.

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Chardon, OH, United States of America

Tim N Ziegenfuss