Cv Therapeutics, Inc.

Gilead Sciences, Inc.

Tim Marquart

Jeff A Zablocki

Elfatih O Elzein

Venkata Poornapragnacharyulu Palle

Prabha N Ibrahim

Rao V Kalla

Xiaofen Li

Brent K Blackburn

Thao Perry

Robert H Jiang

Elfaith O Elzein

Grigory Nudelman

Disclosed are processes for the synthesis of novel compounds that are Aadenosine receptor antagonists, useful for treating various disease states, including asthma and diarrhea.

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Disclosed are novel compounds that are Aadenosine receptor antagonists having the following structure: wherein Rand Rare independently chosen from hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted aryl, and optionally substituted heteroaryl, and Ris an optionally substituted heteroaryl moiety. The compounds of the invention are useful for treating various disease states, including asthma, chronic obstructive pulmonary disorder, pulmonary inflammation, emphysema, diabetic disorders, inflammatory gastrointestinal tract disorders, immunological/inflammatory disorders, cardiovascular diseases, neurological disorders, and diseases related to angiogenesis.

Disclosed are novel heterocyclic compounds having the structure which are useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermittent claudication, Prinzmetal's (variant) angina, stable and unstable angina, exercise induced angina, congestive heart disease, and myocardial infarction. The compounds are also useful in the treatment of diabetes.

Substituted heterocyclic compounds

Disclosed are processes for the synthesis of novel compounds that are Aadenosine receptor antagonists, having the structure of Formula I or Formula II: by cyclizing a compound of the formula (3): 

Disclosed are novel heterocyclic derivatives, useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermittent claudication, Prinzmetal's (variant) angina, stable and unstable angina, exercise induced angina, congestive heart disease, and myocardial infarction. The compounds are also useful in the treatment of diabetes.

Novel compounds of the general formula:and pharmaceutically acceptable acid addition salts thereof, wherein the compounds are useful in therapy to protect skeletal muscles against damage resulting from trauma or to protect skeletal muscles subsequent to muscle or systemic diseases such as intermittent claudication, to treat shock conditions, to preserve donor tissue and organs used in transplants, in the treatment of cardiovascular diseases including atrial and ventricular arrhythmias, Prinzmetal's (variant) angina, stable angina, and exercise induced angina, congestive heart disease, and myocardial infarction.

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Santa Clara, CA, United States of America

Tim Marquart