Cytiva Sweden Ab

Ge Healthcare Bio-sciences Ab

Tim Francois

Mats Lundkvist

Bjorn A Johansson

Kerstin Elisabet Erickson

Lars Olof Nils Rosengren

Klaus Gebauer

Bjorn Markus Olovsson

Tomas Yngve Agren

Nils Stafstrom

Andreas Torbjorn Lundin

Yngve L Hareland

Anna Andersson

Anita Jonsson

Jeanne Cheng

Kerstin Erickson

Disclosed are chromatography systems employing a releasable couplingfor holding a fluid tubing to a spigot, the coupling comprising: a cylindrical inner componentfor accepting a fluid tubing, said inner component including a resiliently deflectable portionarranged to urge an outer surface of the tubing toward a spigot; and a cylindrical collarhaving and internal through-aperturefor slideably accepting the inner component, the aperture and resilient portion having complementary surface formations which in a first position of the collar mounted to the inner component provide for said resilient deflection in use, and which in a second different position do not cause said deflection, the coupling being characterized in that the collar comprises a collar flangeextending outwardly away from the aperture of a size allowing manual manipulation of the collar between the first and second positions. Chromatography systems employing said couplings is disclosed also.

Chromatography system and couplings therefor

A flow distribution device for bioprocess systems, comprising: ⋅—a flow distribution manifold () comprising: ⋅o at least four fluid connection tubes (), wherein each fluid connection tube () comprises a first end () for fluid connection and an opposite second end () ⋅o a central common compartment () to which the second ends () of each of the fluid connection tubes () are connected, whereby the first ends () of each of the fluid connection tubes () can be in fluid communication with the central common compartment () ⋅—at least three pinching members () which are provided in connection with one fluid connection tube () of the flow distribution manifold () each, wherein each of said pinching members () can be controlled into at least a first and a second position, wherein in the first position for each of the pinching members () the pinching member pinches one of the fluid connection tubes () such that fluid flow is prevented between the first end () and the second end () of this fluid connection tube ().

Device for distributing a flow

Disclosed is a chromatography system () comprising: plural modules (-) including at least one pump and a column valve unit () connectable to plural chromatography columns; and a controller (), the controller being operable to control the or each pump and the column valve to perform different chromatographic processes, including chromatography employing just one column, as well as chromatography employing two or more columns by selective valve opening in said unit. The system includes a housing () into which the plural modules (-) are interchangeably mountable in apertures of one generally vertical face of housing, the modules are adapted for selective fluidic interconnection by tubing substantially at said one face such that in use the modules and tubing occupy a generally vertically extending volume to minimize the footprint of the system.

Chromatography apparatus

The present invention relates to a valve unit () for a chromatography apparatus, the valve unit comprising a fluid inlet () configured to receive an input fluid, a fluid outlet () configured to provide an output fluid, a first pair of fluid ports () configured to be coupled to a first column, a second pair () of fluid ports configured to be coupled to a second column, a coupling valve assembly () configured to direct fluid between a selection of the fluid inlet (), the fluid outlet (), the first pair of fluid ports () and the second pair of fluid ports () in response to one or more control signals, wherein the coupling valve assembly is configured to direct fluid using a selection of membrane valves coupled by fluid channels comprised in a body of the coupling valve assembly. The invention further relates to a chromatography apparatus comprising the valve unit and a membrane valve comprised in the valve unit.

Valve unit for a chromatography apparatus

Disclosed are chromatography systems employing a releasable coupling () for holding a fluid tubing to a spigot, the coupling comprising: a cylindrical inner component () for accepting a fluid tubing (), said inner component including a resiliently deflectable portion () arranged to urge an outer surface of the tubing toward a spigot; and a cylindrical collar () having and internal through-aperture () for slideably accepting the inner component, the aperture and resilient portion having complementary surface formations which in a first position of the collar mounted to the inner component provide for said resilient deflection in use, and which in a second different position do not cause said deflection, the coupling being characterized in that the collar comprises a collar flange () extending outwardly away from the aperture of a size allowing manual manipulation of the collar between the first and second positions. Chromatography systems employing said couplings is disclosed also.

Tube coupling

Growing community of inventors

Uppsala, Sweden

Tim Francois