Hoffmann-la Roche Inc.

Tim Dreckmann

Joerg Luemkemann

Hanns-Christian Mahler

Michael Adler

Adeline Boillon

Imke Sonja Ludwig

Julien Boeuf

Alexander Meyer

Anke Dorn

Karoline Bechthold-peters

Andreas Ernst

Denis Luthringer

A process of assembling a filling system for low volume filling of a liquid into a container is disclosed. The process includes obtaining plural liquid forwarding devices configured to provide the liquid from a reservoir to the container, and simulating operation of each of the liquid forwarding devices by numerically modelling flow patterns of the liquid when being forwarded by the liquid forwarding devices, and by determining a shear stress rate for each of the liquid forwarding devices based on the modelled flow patterns. The process further includes determining an appropriateness for each of the liquid forwarding devices by comparing operation parameters of the liquid forwarding of the liquid forwarding devices, wherein the operation parameters include the determined shear stress rates, selecting the liquid forwarding device having the highest determined appropriateness, and installing the selected liquid forwarding device into the filling system.

Low volume filling of a liquid into a container

A dosing system for transferring an aseptic fluid in dosages into a container, comprising a peristaltic pump configured such that the filling accuracy for fill volumes of the aseptic fluid<100 μL is ±3 μL.

Microdosing

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Basel, Switzerland

Tim Dreckmann