Warner-Lambert Company

Tim A Smitka

James C French

Josefino B Tunac

Richard H Bunge

Christopher Franklin Bigge

Edward Faith Elslager

Gerard C Hokanson

Timothy R Hurley

John H Wilton

Blanche D Graham

Russell J Bloem

Stephen W Mamber

Acids, esters, imine acids, imine esters, and imine amides derived from 6-formyl-4,7,9-trihydroxy-1-phenazinecarboxylic acid, methyl ester and from 6-formyl-4,7,9-trihydroxy-8-methyl-1-phenazinecarboxylic acid, methyl ester demonstrate antimicrobial and antineoplastic activity. A purified strain of Streptomyces galanosa, NRRL 15738, is capable of producing 6-formyl-4,7,9-trihydroxy-8-methyl-1-phenazinecarboxylic acid, methyl ester in isolable quantities from a fermentation broth containing assimilable sources of carbon and nitrogen.

Antimicrobial and antitumor phenazine carboxaldehydes and derivatives

A purified isolate of an actinomycete identified as ATCC 39363 is capable of producing a complex of sulfur-containing antibiotic compounds having activity against transplanted tumors. Antibiotic compounds CL-1577A and CL-1577B and their closely related congeners are produced by cultivating isolate ATCC 39363 under aerobic conditions in a culture medium containing assimilable sources of carbon and nitrogen until a substantial quantity of the CL-1577 complex is produced, and subsequently isolating the complex or one or more of the compounds. The antibiotic compounds CL-1577A, CL-1577B, their congeners, and pharmaceutical compositions comprising these substances together with a suitable carrier are also disclosed.

CL-1577 Antibiotic compounds and their production

The present invention relates to the novel trichothecenes, 12'-hydroxyverrucarin J and iso-satratoxin H, and a fermentation process for the production of said compounds. The invention also relates to pharmaceutical compositions comprising said compounds and methods for using said compositions.

12'-Hydroxyverrucarin J and iso-satratoxin H

Growing community of inventors

Ann Arbor, MI, United States of America

Tim A Smitka