University of Maastricht

Academisch Ziekenhuis Maastricht

Pepscan Systems B.v.

Tilman Mathias Hackeng

Wouter Cornelis Puijk

Arjan Willem Griffioen

Peter Timmerman

Wessel Matthijs Blankesteijn

Hilde Laeremans

The invention relates to the fields of protein chemistry, biology and medicine. More specifically, it relates to the design and preparation of proteinmimics of members of the cystine-knot growth factor superfamily. Further, the invention relates to the use of these proteinmimics as a medicament or prophylactic agent. The invention provides proteinmimics of members of the cystine-knot growth factor superfamily, preferably for use in immunogenic and/or therapeutic compositions.

Truncated cystine-knot proteins

The invention is in the field of molecular medicine. It provides antagonistic compounds for frizzled 1 and/or frizzled-2 receptors, which may be useful in molecular imaging of the wound healing process after myocardial infarction and in therapeutic intervention into wound healing after remodeling of the heart, thereby ameliorating the consequences of myocardial infarction. The invention provides a method for antagonizing frizzled-1 or frizzled-2 receptors, wherein the receptor is contacted with a composition comprising a linear fragment of Wnt3(a) or Wnt5a or a functional analogue thereof, which comprises at least one cysteine residue, one threonine residue, one aspartic acid residue and one glycine residue.

Antagonistic peptides for frizzled-1 and frizzled-2

Growing community of inventors

Maastricht, Netherlands

Tilman Mathias Hackeng