Amlika Mercantile Private Limited

Rheinisch-westfaelische Technische Hochshule Aachen (rwth)

Till Tiso

Lars Mathias Blank

Andrea Germer

Susanne Wilhelm

Andreas Wittgens

Frank Rosenau

The present invention relates to a host cell comprising an rhlA gene or an ortholog thereof that is capable of producing hydroxyalkanoyloxy alkanoic acid (HAA) and achieving an HAA concentration of more than 1 g Lwhen cultured. The invention further relates to methods of producing such a host cell and to the use of said host cell for producing HAA. The present invention also relates to methods of producing HAA using said host cell, HAA compositions produced by these methods, as well as methods of producing fatty acid compositions, fatty alcohol compositions, or hydrocarbon compositions comprising producing HAA using said host cell, and fatty acid compositions, fatty alcohol compositions, or hydrocarbon compositions produced by said methods.

Extracellular production of designer hydroxyalkanoyloxy alkanoic acids with recombinant bacteria

Provided is a host cell comprising a rhlA gene or an ortholog thereof, under the control of a heterologous promoter and a rhlB gene or an ortholog thereof, under the control of a heterologous promoter. The host cell is capable of achieving a carbon yield of more than 0.18 Cmol rhamnolipid/Cmol substrate. Provided is also a method of producing rhamnolipids, employing such a host cell.

Means and methods for rhamnolipid production

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Cologne, Germany

Till Tiso