Lek Pharmaceuticals D.d.

Sandoz Ag

Tijana Stanic Ljubin

Tanja Rozman Peterka

Sandra Berglez

Uros Klancar

Klemen Kocevar

Rok Staric

Rok Grahek

Luka Peternel

Jernej Grmas

Polona Smrdel

The present invention relates to a pharmaceutical composition, preferably a pharmaceutical dosage form, comprising at least two separate compartments, wherein one compartment contains a composition comprising metformin or a pharmaceutically acceptable salt thereof and wherein another compartment contains a composition comprising sitagliptin. The present invention also relates to a process for preparing dosage forms comprising metformin or a pharmaceutically acceptable salt thereof and sitagliptin or a pharmaceutically acceptable salt thereof, the process comprising the steps of: The present invention also refers to a process for preparing dosage forms comprising at least one compartment comprising metformin or a pharmaceutically acceptable salt thereof and sitagliptin or a pharmaceutically acceptable salt thereof, the process comprises providing a composition containing metformin or a pharmaceutically acceptable salt thereof, and sitagliptin or a pharmaceutically acceptable salt thereof, and a matrix agent. Moreover, the present invention related to a dosage form obtained by said process, and to the use of said dosage form for the treatment of diabetes.

Pharmaceutical compositions comprising a combination of metformin and sitagliptin

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Ljubljana, Slovenia

Tijana Stanic Ljubin