Gruenenthal Gmbh

Gruenethal Gmbh

Grunenthal Gmbh

Tieno Germann

Stefan Schunk

Ruth Jostock

Melanie Reich

Sabine Hees

Michael Engels

Stefan Oberboersch

Klaus Schiene

Jean De Vry

Oswald K Zimmer

Stefanie Frosch

Edward Bijsterveld

Michael Franz-Martin Engels

Bernd Sundermann

Thomas Christoph

Achim Kless

Joerg Holenz

Corinna Maul

Christa Kneip

Heinrich Helmut Buschmann

Guenter Werner Englberger

Erik James Wade

Helmut Heinrich Buschmann

Hagen-Heinrich Hennies

Beatrix Merla

Helmut Buschmann

Heinrich Kugelmann

Fritz Theil

Stefan Oberbörsch

Elke Janocha

Hagen-Henrich Hennies

Ellen Klegraf

Kamila Hennig

Substituted benzamide compounds corresponding to formula (I) in which R5, R6, R7, R8, a, b, c, d, t, D and X have defined meanings, a process for their preparation, pharmaceutical compositions comprising such compounds, and a method of using such compounds to treat pain and other conditions mediated at least in part via the bradykinin 1 receptor.

Bradykinin 1 receptor modulating compounds

Substituted sulfonamide compounds with bradykinin receptor (B1R) modulating activity; processes for the preparation thereof, pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat or inhibit pain and/or other disorders and/or disease states.

Substituted sulfonamide compounds

Substituted 1-oxa-2,8-diaza-spiro[4,5]dec-2-ene compounds and processes for their production, the use thereof for producing pharmaceutical compositions, pharmaceutical compositions containing these compounds and methods of treatment using these compounds.

Substituted 1-oxa-2,8-diaza-spiro [4,5] dec-2-ene derivatives and related treatment methods

Substituted sulfonamide compounds corresponding to the formula I processes for the preparation thereof, pharmaceutical compositions containing these compounds and the use of substituted sulfonamide compounds for the preparation of pharmaceutical compositions for treating pain and other conditions at least partly mediated via the bradykinin 1 receptor.

Substituted indole compounds corresponding to the formula I: In which R, R, R, R, R, R, R, A, D, T, q, s and t have defined meanings, processes for the preparation thereof, pharmaceutical compositions containing such compounds and the use of substituted indole compounds for the treatment or inhibition of pain and other conditions which are at least partly mediated by Bradykinin 1 receptors (B1R).

Substituted indole compounds

Substituted spiro-amide compounds corresponding to formula I in which R5 through R8, D, X, Y and Z have defined meanings, processes for preparing such spiro-amide compounds, pharmaceutical compositions containing such compounds, and methods of using such spiro-amide compounds for treating and/or inhibiting disorders or disease states mediated at least in part by the bradykinin 1 receptor.

Substituted spiro-amide compounds

Substituted sulfonamide derivatives, a process for their preparation, pharmaceutical compositions containing these compounds, and to the use of substituted sulfonamide derivatives in the treatment or inhibition of pain and/or various disorders or disease states.

Substituted spiroamide compounds corresponding to formula (I): wherein A, B, Q, Q, Q, Q, R, R, R, R, R, R, Rand Rhave defined meanings, processes for their preparation, pharmaceutical compositions containing such compounds, and the use of such compounds for treating or inhibiting pain or other conditions mediated at least in part by the bradykinin 1 receptor (B1R).

Spiro group-containing amide compounds having bradykinin 1 receptor (B1R) activity

Substituted sulfonamide compounds corresponding to formula I: processes for the preparation thereof, pharmaceutical compositions containing these compounds, and the use of such substituted sulfonamide compounds in pharmaceutical compositions for the treatment and/or inhibition of pain and other conditions at least partly mediated by the bradykinin 1 receptor.

Substituted pyrimidine and triazine compounds corresponding to formula I wherein R, R, R, R, R, R, R, R, R, R, R, R, R, A, a, b, s, t, V, W, Wand Whave defined meanings, pharmaceutical compositions comprising such compounds, a process for preparing such compounds, and the use of such compounds and compositions to treat or inhibit pain and/or other disorders or disease states.

Substituted pyrimidine and triazine compounds

Substituted sulfonamide compounds corresponding to formula I processes for the preparation thereof, pharmaceutical compositions containing such compounds, and the use of such compounds for treating and/or inhibiting pain or other conditions at least partly mediated by the bradykinin 1 receptor.

Substituted benzimidazoles, benzothiazoles and benzoxazoles, processes for their preparation, pharmaceutical compostions containing these compounds and the use of these compounds for treating or inhibiting disorders or disease states mediated at least in part by bradykinin receptor 1 (BR1).

Substituted benzimidazoles, benzothiazoles and benzoxazoles

Sulfonylated tetrahydroazolopyrazine compounds corresponding to the formula I wherein R, R, R, R, R, R, R, R, R, R, R, A, B, W, Wand Whave the meanings defined herein, pharmaceutical compositions containing such compounds, a method for the preparation of such compounds, and the use of such compounds for treating or inhibiting various types of pain and/or other conditions mediated at least in part by the bradykinin 1 receptor (B1R).

Sulfonylated 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine compounds and their use as pharmaceuticals

Substituted sulfonamide compounds corresponding to formula I: a process for their preparation, pharmaceutical compositions comprising such compounds, and the use of such substituted sulfonamide compounds in pharmaceutical compositions for the treatment of pain or other disorders or diseases that are mediated at least in part by B1R receptors.

Substituted disulfonamide compounds corresponding to formula I: In which R, R, R, R, R, R, R, R, R, R, R, R, a, b, s, t and A have defined meanings, pharmaceutical compositions containing one or more such compounds, processes for preparing such compounds, and a method of using such compounds for the treatment or inhibition of pain and/or other conditions mediated by the bradykinin receptor 1 (BR1).

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