International Business Machines Corporation

Tien Huynh

Isidore Rigoutsos

Kevin Charles Miranda

Aristotelis Tsirigos

Alice Carolyn McHardy

Andrew William Senior

Stanislav Polonsky

Robert Evan Strom

Yiming Ye

Daniel M Yellin

Michal Z Ukelson

Sequences of ribonucleic acid interference molecules are provided. For example, in one aspect, at least one nucleic acid molecule comprising at least one of one or more precursor sequences having SEQ_ID NO: 1 through SEQ_ID NO: 3,197 and one or more corresponding mature sequences having SEQ_ID NO: 3,198 through SEQ_ID NO: 6,565 is provided. Techniques are also provided for regulating gene expression.

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Sequences of ribonucleic acid interference molecules are provided. For example, in one aspect, at least one nucleic acid molecule comprising at least one of one or more precursor sequences having SEQ_ID NO: 1 through SEQ_ID NO: 11,928 and one or more corresponding mature sequences having SEQ_ID NO: 11,929 through SEQ_ID NO: 24,555 is provided. Techniques are also provided for regulating gene expression.

A method for determining whether a nucleotide sequence contains a microRNA binding site and which microRNA will bind thereto is provided. For example, in one aspect of the invention, a method for determining whether a nucleotide sequence contains a microRNA binding site and which microRNA sequence will bind thereto is comprised of the following steps. One or more patterns are generated by processing a collection of known mature microRNA sequences. The reverse complement of each generated patter is then computed. One or more attributes are then assigned to the reverse complement of the one or more generated patterns. The one or more patterns that correspond to a reverse complement having one or more assigned attributes that satisfy at least one criterion are thereafter subselected. Each subselected pattern is then used to analyze the nucleotide sequence, such that a determination is made whether the nucleotide sequence contains a microRNA binding site and which microRNA sequence will bind thereto.

System and method for identification of microRNA target sites and corresponding targeting microRNA sequences

Ribonucleic acid interference molecules are provided. In one aspect of the invention, a method for regulating gene expression comprises the following step. At least one nucleic acid molecule comprising at least one of one or more precursor sequences having SEQ ID NO: 1 through SEQ ID NO: 103,948, each one of the precursor sequences containing one or more mature sequences having SEQ ID NO: 103,949 through SEQ ID NO: 230,447, is used to regulate the expression of one or more genes.

Ribonucleic acid interference molecules

A method and system are disclosed for matching input character sequences in a set of input patterns. The method comprises the steps of analyzing the set of input patterns, creating a pattern cluster look-up table (PCLT) based on said input patterns, and defining an offset value k. The PCLT is used to find, for each sequence s and offset k, a set of candidate patterns that can possibly match s, the set of candidate patterns is searched for patterns that match s, and all found matching patterns and sequences are reported.

Method and apparatus for matching of bracketed patterns in test strings

In one aspect of the invention, a method for regulating the expression of a transcript comprises using at least one interfering RNA molecule that binds to an area of transcript containing a region that corresponds to at least one sequence having SEQ ID NO: 1, the interfering RNA molecule regulating the expression of the transcript through post-transcriptional silencing. In another aspect, a method for regulating the expression of a transcript comprises at least one of the provided sequences having SEQ ID NO: 1 being used to design an interfering RNA molecule that contains a region that corresponds to the reverse complement of one or more sequences having SEQ ID NO: 1, the interfering molecule regulating, through post-transcriptional silencing, transcripts that contain the sequence having SEQ ID NO: 1.

Ribonucleic acid interference molecules and binding sites derived by analyzing intergenic and intronic regions of genomes

Techniques for linking non-coding and gene coding regions of a genome are provided. In one aspect, a method of determining associations between non-coding sequences and gene coding sequences in a genome of an organism comprises the following steps. At least one conserved region is identified from one or more non-coding sequences. Additional instances of the conserved region are located in the untranslated or amino acid coding regions of one or more genes in the organism under consideration, and the conserved region is associated with the one or more biological processes in which these one or more genes participate.

Techniques for linking non-coding and gene-coding deoxyribonucleic acid sequences and applications thereof

An apparatus for implementing 'links' between objects or content items in applications or documents in a distributed system such that changes to the source objects or items are reflected in changes to the target objects or content items. The apparatus includes mechanisms for allowing users to establish links, to break individual links, to copy documents or content including links, and to determine locations and/or descriptions of the source of a given target or any or all of the multiple targets of a given source. Advantageously, the apparatus of this invention uses remote message passing for communication, thereby permitting links to be established even when the source and target applications execute on different platforms and even when they share no common file system. The apparatus includes an availability server which can serve as a surrogate for applications which are currently not running. This permits targets of links to query the state of a link source, to register/unregister with the link source in order to receive notification of updates, create new links linked to the same link source, and to break their link to the link source, even though the application containing the link source is unavailable. The apparatus of the availability server can be generalized to support the ability to support transparent access from one application to objects of a second application in the face of unavailability of the second application.

Method and apparatus for linking data in a distributed data processing system

An intelligent screen saver utility that is less obtrusive than conventional screen savers is based on the absence of an operator rather than a predetermined time period for activation and detects the presence of the operator for deactivation. The screen saver is totally transparent in use to the operator and requires no touching of the keyboard or mouse movement to either prevent activation or deactivation of the screen saver. The screen saver requires a camera that can grab images. The images are grabbed and temporarily stored in the computer memory. When the difference between successively grabbed images is big enough, a person's presence is detected. When there is no big difference between successive images during a given time period, a person's absence is detected. The presence status is used to control the status of the screen saver.

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Yorktown Heights, NY, United States of America

Tien Huynh