Peking University

Zhengzhou Granlen Pharmatech. Ltd.

Zhengzhou Anshuangyunping Pharmatech, Ltd.

Tieming Cheng

Runtao Li

Zemei Ge

Jingrong Cui

Xin Wang

Qi Sun

Haoyun An

Jia Ye

Liqiang Han

Yongqiang Zhu

Shuyang Yao

Caiqin Yue

Changling Li

The present invention provides a urea peptidomimetic boronic compound and pharmaceutical compositions thereof, their preparative methods and uses. The compounds are represented by the following formula (I). 

Urea peptoid boric acid compound, pharmaceutical composition thereof, preparation method therefor, and uses thereof

The present invention discloses proteasome inhibitors of tripeptide boronic acids or boronic esters represented by Formula (I), preparative method and use thereof. The proteasome inhibitors are therapeutical agents for treating malignant tumor, various nervous system degenerative diseases, muscle cachexia or diabetes, wherein the malignant tumor is leukemia, gastric cancer, hepatocarcinoma or nasopharyngeal carcinoma. 

Tripeptide boronic acid or boronic ester, preparative method and use thereof

Compounds represented by general formula (I), their stereoisomers, tautomers, derivatives, prodrugs or pharmaceutically acceptable salts, and their preparation methods or uses for the manufacture of a medicament of analgesics. In which Ris selected from H, substituted or unsubstituted phenyl, or substituted or unsubstituted heteroaryl; A is bond, or saturated or unsaturated straight-chain or branched-chain hydrocarbon radical; R, Rare each independently hydrogen or methyl, which linked with any position of spirocyclo-structure; n and m are each independently integer between 0-2, do not represent 0 at the same time; B and D are each independently C-Cstraight-chain or branched-chain alkylene; Y is selected from &#x2014;CHR&#x2014;, O, S, &#x2014;S(O)&#x2014;, &#x2014;SO&#x2014;, &#x2014;NR&#x2014; and substituted or unsubstituted phenylene, in which Rrepresents H, C-Csaturated or unsaturated alkyl, methyl or ethyl substituted by substituted or unsubstituted aryl or heteroaryl; and Xis pharmaceutical acceptable organic or inorganic anion. These compounds can be used as muscarine receptor (M-receptor) and/or nicotine acetylcholine receptor (N-receptor) agonist or antagonist. These compounds have good analgesic effect without side effect such as addiction. 

Quaternary ammonium salt compounds of spirocyclopiperazines, preparation methods and uses thereof

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Beijing, China

Tieming Cheng