Amgen Inc.

E. R. Squibb Sons, Inc.

Medarex Inc.

Tie J Zhang

Haichun Huang

Frank Martin

Kenneth D Wild, Jr

Heather Inoue

James J S Treanor

James Js Treanor

This invention provides antibodies that interact with or bind to human nerve growth factor (NGF) and neutralize the function of NGF thereby. The invention also provides pharmaceutical compositions of these antibodies and methods for neutralizing NGF function, and particularly for treating NGF-related disorders (e.g., chronic pain) by administering a pharmaceutically effective amount of anti-NGF antibodies. Methods of detecting the amount of NGF in a sample using anti-NGF antibodies are also provided.

Methods of treating conditions caused by increased expression of nerve growth factor (NGF) or increased sensitivity to NGF using anti-NGF neutralizing antibodies as selective NGF pathway inhibitors

This invention provides antibodies that interact with or bind to human nerve growth factor (NGF) and neutralize the function of NGF thereby. The invention also provides pharmaceutical compositions of said antibodies and methods for neutralizing NGF function, and particularly for treating NGF-related disorders (e.g., chronic pain) by administering a pharmaceutically effective amount of anti-NGF antibodies. Methods of detecting the amount of NGF in a sample using anti-NGF antibodies are also provided.

Human anti-NGF neutralizing antibodies as selective NGF pathway inhibitors

Nucleic acids encoding human anti-NGF neutralizing antibodies as selective NGF pathway inhibitors

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Thousand Oaks, CA, United States of America

Tie J Zhang