Monsanto Technology LLC

Tichafa R I Munyikwa

James Kevin Roberts

James Arthur Baum

Larry A Gilbertson

Wei Wu

David K Kovalic

Maolong Lu

Bei Zhang

Thomas J Larosa

Thomas J LaRosa

Gregory R Heck

Ty T Vaughn

Jean C Goley

Joanne J Fillatti

Toni Alols Voelker

Scott C Johnson

The present invention is directed to controlling pest infestation by inhibiting one or more biological functions in an invertebrate pest. The invention discloses methods and compositions for use in controlling pest infestation by feeding one or more different recombinant double stranded RNA molecules to the pest in order to achieve a reduction in pest infestation through suppression of gene expression. The invention is also directed to methods for making transgenic plants that express the double stranded RNA molecules, and to particular combinations of transgenic pesticidal agents for use in protecting plants from pest infestation.

Compositions and methods for control of insect infestations in plants

This invention relates to methods of controlling gene expression or gene suppression in eukaryotic cells. One aspect of this invention includes modifying the degree of silencing of a target gene by use of a modified suppression element. Another aspect includes providing a eukaryotic cell having a desired phenotype resulting from transcription in the eukaryotic cell of a modified suppression element. Also provided are transgenic eukaryotic cells, transgenic plant cells, plants, and seeds containing modified suppression elements, and useful derivatives of such transgenic plant cells, plants, or seeds, such as food or feed products.

Modified gene silencing

The invention provides methods for selecting nucleotide sequences that yield dsRNA-mediated gene suppression in a target organism and enable their uptake by the target organism. The invention further provides expression constructs that confer stabilized expression of such sequences in a transgenic host cell, and methods for their use. Also provided are organisms, cells and tissues prepared by a method of the invention.

Selecting and stabilizing dsRNA constructs

Growing community of inventors

Ballwin, MO, United States of America

Tichafa R I Munyikwa