Sanofi-aventis

Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt.

Euroapi Hungary Limited Liability Company

Egis Gyogyszergyar Zrt.

Tibor Szabó

Gyula Simig

Zsuzsanna Kardos

Irén Hortobágyi

Lajos T Nagy

Zoltán Szlávik

Endre Mikus

Tamás Bán

Imre Bata

József Barkóczy

Balázs Volk

László Szlávik

Sándor Bátori

Gyula Lukács

Imre Rozsumberszki

Csaba Váradi

Ervin Vajda

László Balázs

Zoltán Kapui

Katalin Urbán-Szabó

Géza Timári

Péter Arányi

György Ruzsics

Melinda Nagy

Márton Varga

Edit Susán

Éva Boronkay

László Fónagy

Mária TÓTHNÉ Lauritz

András Boza

Mária KOVÁCS

Laszló PongÓ

Imre KIRÁLY

László Hanák

Bernadett Szabóné Ravasz

Gábor Kozma

Zoltán Molnár

Andrásné Strbka

Tibor Szánya

Katalin Urbán Szabó

Michel Finet

The present invention relates to a process for the preparation of iloprost of formula I through new intermediates, isolation of iloprost of formula I in solid form, as well as preparation of the 16(S)-iloprost and 16(R)-iloprost isomers of formulae (S)-I and (R)-I and isolation of iloprost of formula I and 16(S)-iloprost of formula (S)-I in solid, crystalline form.

Process for the preparation of iloprost

The present invention relates to a process for the preparation of iloprost of formula I through new intermediates, isolation of iloprost of formula I in solid form, as well as preparation of the 16(S)-iloprost and 16(R)-iloprost isomers of formulae (S)-I and (R)-I and isolation of iloprost of formula I and 16(S)-iloprost of formula (S)-I in solid, crystalline form. 

Heterocyclic amides useful as inhibitors of dipeptylpeptidase-IV (DPP-IV) enzyme, process for the preparation thereof and intermediates therefore.

Compounds

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Budapest, Hungary

Tibor Szabó