Egis Gyogyszergyar

Biogal Gyogyszergyar

Richter Gedeon Vegyeszeti Gyar Rt

Egyt Gyogyszervegyeszeti Gyar

Gyogyszerkutato Intezet

Richter Cedeon Vegveszeti

Tibor Lang

Imre Moravcsik

Tamas Hamori

Jeno Korosi

Istvan Elekes

Gabor Ambrus

Peter Botka

Gabor Zolyomi

Zsuzsanna Lang Nee Rihmer

Ferenc Andrasi

Lajos Toldy

Pal Berzsenyi

Tibor Balogh

Jozsef Reiter

Katalin Goldschmidt

Gyorgy Rabloczky

Maria Kuhar Nee Kurthy

Istvan Ott

Kalman Harsanyi

Gyorgy Fekete

Bela Hegedus

Istvan M Szabo

Endre Kasztreiner

Gyorgy Domany

Istvan Horvath

Sandor Elek

Eva Againe Csongor

Janos Borvendeg

Istvan Polgari

Laszlo Pongo

Karoly Albrecht

Jozsef Borsi

Istvan Ling

Eva Ilkoy

Geza Szilagyi

Andras Varro

Istvan Gado

Margit Bidlo Nee Igloy

Jozsef Szekely

Antonia Jekkel Nee Bokany

Ferenc Morasz

Emilia Simonovits

Gyorgy Botond Kiss

Lajos Ila

Kalman Konczol

Judit Sarossy Nee Kincsesy

Csaba Kari

Ferene Andrasi

Arpad Lazar

Lajos Ferenczy

Gabor Hantos

Gyorgy Szvoboda

Eleonora Sineger

Andras Rado

Judit Sarossy Nee Kincsessy

Antal Mai

Katalin G Horvath

Eva Csajagi

Zsuzsanna L Rihmer

Zsuzesanna Vida

Janos Dohy

Sandor Szentmihalyi

Janos Seregi

Lajos Alfoldi

Krisztina Heltai

Zsuzsanna Lengyel Nee Szemenyei

Istvan Torok

Katalin Balint Nee Fodor

Tamas Somorai

Tibor Somogyi

Oszkar Fuchs

The invention relates to a composition for improving the efficiency of ruminant feed utilization, which comprises as active ingredient one or more microbial cultures, capable of adjusting the weight ratio of acetic acid to propionic acid to an optimum value, preferably to 1.5-4.0:1, and of growing in the rumen and persisting there at least for 60 days, optionally in admixture with carriers, diluent, preserving agents conventionally used in animal husbandry and nutritive and/or other substances conventionally administered to ruminants. According to another aspect of the invention there is provided a process for the preparation of microbial cultures used as active ingredient in the above composition. The invention further relates to a process for the preparation and use of said compositions.

Composition and method for improving the efficiency of ruminant feed

The invention relates to a process for the production of 9.alpha.-hydroxy-4-androstene-3,17-dione from natural sterols of plant or animal origin or from mixtures thereof by the submerged aerobic fermentation of an enzyme-deficient, sterol-de-grading microorganism in a nutrient medium containing utilizable carbon and nitrogen sources as well as mineral salts, and by isolating the product formed, which comprises transforming the sterol or sterol mixture with the culture of a 1,2-steroid-dehydrogenase deficient strain of new Mycobacterium roseum species which is able to degrade the side-chain of natural sterols, preferably with Mycobacterium roseum sp. nov. 1108/1 deposited at the National Collection of Agricultural and Industrial Microorganisms, Budapest, Hungary under the number NCAIM B (P) 000339, and by isolating and purifying the 9.alpha.-hydroxy-4-androstene-3,17-dione obtained.

Microbiological process for preparing

This invention relates to new 1-(hydroxystyryl)-5H-2,3-benzodiazepine derivatives of the general formula (I) and to a process for the preparation thereof, furthermore to pharmaceutical compositions containing the same, ##STR1## wherein R stands for a hydrogen or halogen atom, or a C.sub.1-4 alkoxy group,

1-(hydroxystyrl)-5H-2,3-benzodiazepine derivatives, and pharmaceutical

The invention relates to new 1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-3,4-dihydro-5H-2,3-benzodiaz epi ne of formula (1), optically active isomers and acid addition salts thereof as well as to pharmaceutical compositions containing these compounds. ##STR1## The new compounds of formula (I) can be prepared by reducing 1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine of formula (II) with an inorganic or organic-inorganic and/or complex metal hydride and, if desired, separating the optically active forms of the compound of formula (I) thus-obtained and, if desired, converting the base or bases into acid addition salts or converting the salts into the free bases(s). ##STR2## The new compound of formula (I) possesses significant central nervous effects and can advantageously be used in the therapy.

1-(4-Aminophenyl)-4-methyl-7,8-methylenedioxy-3,4-dihydro-5H-2,3-b

This invention relates to new 3-(hydroxymethyl)-isoquinoline derivatives of the general formula (I), their acid addition salts, and to a process for the preparation thereof, furthermore to pharmaceutical compositions containing the same, ##STR1## wherein R and R.sup.1 are identical or different and stand for a hydrogen or halogen atom, a nitro or a C.sub.1-4 alkoxy group,

3-(hydroxymethyl)-isoquinoline derivatives

A process for the production of aminoglycoside antibiotics using fused protoplasts derived from streptomyces. The cells are precultured in a medium containing sucrose, calcium and magnesium salts. Protoplasts are formed and then fused. The fused protoplasts are regenerate and antibiotic producing ability is screened for. The regenerate cells produced an antibiotic complex of modified composition or demonstrated increased or reduced antibiotic productivity compared to the fusion partners.

Process for the improvement of antibiotic production by in vivo genetic

The invention relates to new 5H-2,3-benzodiazepine derivatives and a process for the preparation thereof, furthermore to pharmaceutical compositions containing the same. The new 5H-2,3-benzodiazepine derivatives of the invention possess valuable central nervous effect and in particular exert antiaggressive, anxiolytic, narcosis potentiating and soporific properties.

5H-2,3-benzodiazepine derivatives and pharmaceutical compositions

The invention relates to the new monohydrate of N-methyl-N'-{2-[(5-methylimidazol-4-yl)-methylthio]-ethyl}-N'-cyanoguanidi ne (cimetidine), a histamine-H.sub.2 receptor antagonist which is called N-methyl-N'-{2-[(5-methylimidazol-4-yl)-methylthio]-ethyl}-N'-cyanoguanidi ne H (cimetidine H) as well as to a process for the preparation of same, which comprises pouring a hot, homogeneous aqueous solution of N-methyl-N'-{2-[(5-methylimidazol-4-yl)-methylthio]-ethyl}-N'-cyanoguanidi ne, optionally containing also methylamine, onto ice and separating the N-methyl-N'-{2-[(5-methylimidazol-4-yl)-methylthio]-ethyl}-N'-cyanoguanidi ne monohydrate.

Cimetidine monohydrate

The invention relates to acylated 1,2,4-triazole derivatives of general formula I ##STR1## wherein R.sup.1 represents an unsubstituted phenyl group or a phenyl group substituted by one or more halogen atoms, lower alkyl, alkoxy, acyloxy, hydroxy, amino, azido, nitro, trifluoromethyl, lower alkylthio, alkylsulfinyl, or alkylsulfonyl group, and

Antiviral acylated 1,2,4-triazole derivatives

The invention relates to new 3,4-dihydro-5H-2,3-benzodiazepine derivatives of general formula (I) and pharmaceutically acceptable acid addition salts thereof, ##STR1## wherein R represents a phenyl group optionally carrying one or two substituents selected from the group consisting of halogen, hydroxy, C.sub.1-4 alkoxy and benzyloxy; a furyl or a thienyl group,

3,4-Dihydro-5H-2,3-benzodiazepine derivatives and pharmaceutical use

The invention provides a process for the preparation of antibiotic-producer Micromonospora strains having modified genetic material, wherein a protoplast suspension is prepared with lysozyme, under osmotically buffered conditions ensured by sucose, from each culture of the two genetically marked mutants of the antibiotic-producer Micromonospora strain following cultivation in a glycine medium, both suspensions obtained are combined in the presence of polyethylene glycol, and incubated at room temperature, the resulting fused protoplasts are suspended in soft agar, then plated on an agar plate containing sucrose, prolin and inorganic salts, incubated for 20 to 30 days, and finally all mutants are selected from the regenerated colonies which are sure to have genetic material different from that of the parent strains. The process can be advantageously applied to improve productivity of antibiotic-producer strains having industrial importance.

Genetic process for the preparation of antibiotic-producer

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Budapest, Hungary

Tibor Lang