Richter Gedeon Vegyeszeti Gyar Rt

Tibor Keve

Csaba Szantay

Lajos Szabo

Lajos Dancsi

Laszlo Szporny

Gyorgy Kalaus

Egon Karpati

Janos Galambos

Gyorgy Fekete

Gabor Megyeri

Ferenc Drexler

Katalin Honty

Bela Kiss

Bela Stefko

Bela Zsadon

Sandor Eckhardt

Janos Sugar

Tibor Acs

Eva Palosi

Erzsebet Lapis

Ferenc Trischler

Erik Bogsch

Tibor Cs

Istvan Laszlovszky

Zsolt Szombathelyi

Dora Groo

Lajos Kovacs

Arpad Kiraly

Maria Zajer Nee Balazs

Zsuzsa Kneffel

Eva Ivan

Gyorgy Hajos

Sandor Gorog

Elemer Ezer

Csaba Lorincz

Eszter Dezseri

Lilla Forgach

Janos Sapi

Bela Rosdy

Gyongyver Kiraly Nee Soos

Sandor Kerpel-Fronius

Zsuzsa Somfai

Ivan Hindi

Anna Kassai Nee Zieger

Hedvig Bolcskei

Aniko Gere

Judit Laszy

Katalin Csomor

Adam Sarkadi

Sandor Szabo

Lilla Forgacs

Maria Gazdag

Gabor Szepesi

Zsolt Szentirmay

Maria Szilasi

Margit Barta Nee Bukovecz

Klara Horvath Nee Otta

Bala Stefko

Margit Barta N/e/ E Bukovecz

Zsuzsa Somjai

Emilia Repasi, Nee Balogh

Anna Kassia Nee Zieger

Viktoria Bolya Nee Kassay

Mih,acu/a/ Ly Bodo

Maria Gazdac

Gyoorgy Kalaus

Zsuzsanna Relle Nee Somfai

Krisztina Mihalyfi

Anna Kassi Nee Zieger

Zsuzsanna Relle Nee Somfa

Lajos Szbao

Ferenc Vezekenyi

Anna Kassainee Zieger

Gyongyver Soos

The invention relates to novel 15-nitro-2.beta.,3.beta.-dihydro- and 15-nitro-2.beta.,3.beta.,6,7-tetrahydrotabersonine derivatives of the formula (I), ##STR1## wherein R.sup.1 stands for hydrogen;

15-nitro-2.beta., 3.beta.-dihydro- and

The invention relates to novel 2-halogenated 8- and 1,8-substituted ergolene derivatives of the formula (I) and the acid addition salts thereof, pharmaceutical compositions containing them and a process for their preparation. In the formula (I) ##STR1## wherein X stands for a halogen;

2-Halogenated-8- and 1,8-substituted ergolenes

The invention relates to a novel process for the halogenation in 2-position of ergot alkaloids. The process is characterized by that as a halogenating agent a system consisting of dimethylsulfoxide, a trialkylhalosilane or triarylhalosilane and optionally a hydrogen halide is used.

Process for the preparation of 2-halogenated ergoline derivatives

The invention relates to a new process for the preparation of 17,18-dehydro-apovincaminol-trimethoxy-benzoate of the formula (I) ##STR1## and acid addition salts thereof. According to the invention compound of the formula (I) is prepared starting from 17,18-dehydrovincamine of the formula (IIa) ##STR2## and/or 17,18-dehydro-epivincamine of formula (IIb) ##STR3## by reducing with a complex metal hydride, acylating the new hydroxy-vincaminol derivative obtained selectively with 3,4,5-trimethoxy-benzoic acid or a derivative thereof capable of acylation, optionally in the presence of a catalyst and/or an acid binding agent, and treating the corresponding acylated hydroxylderivative obtained with formic acid, in the presence of an acid chloride, and, if desired, converting the compound of formula (I) obtained into an acid addition salt thereof.

Process for the preparation of an apovincaminol derivative

The invention relates to novel bis-indole derivatives of the general formula (I) ##STR1## wherein R.sub.1 stands for a hydrogen atom or an acetyl group;

Bis-indole derivatives and pharmaceutical compositions containing them

The invention relates to a novel process for the preparation of partially new 2-halonicergoline derivatives of the formula (I), ##STR1## wherein X stands for chlorine, bromine or iodine atom, as well as their acid addition salts. The process of the invention comprises esterifying a novel 2-halo-1-methyllumilysergol of the formula (II), ##STR2## wherein X is the same as defined above, or an acid addition salt thereof and, if desired, converting the thus-obtained 2-halonicergoline derivative of the formula (I) to an acid addition salt. The compounds of the invention improve the cognitive function of the brain and show an antihypoxic as well as a strong .alpha.-adrenerg blocking and calcium-antagonistic action.

2-chloronicergoline having antihypoxic activity

The invention relates to novel furfuryl derivatives of the general formula (I), ##STR1## wherein R.sub.1 stands for a hydrogen atom or an acetyl group,

Furfuryl derivatives of vinblastine-type bis-indoles, and pharmaceutical

The invention relates to novel nitro derivatives of the general formula (I) ##STR1## wherein R.sub.1 stands for a methyl or a formyl group;

Nitro derivatives of vinblastine-type bisindoles, and pharmaceutical

The invention relates to a novel process for the preparation of 2-bromo-.alpha.-ergocryptine and its acid addition salt by brominating .alpha.-ergocryptine in such a way that the bromination is carried out at room temperature by using a dimethylsulphoxide-hydrogen bromide mixture containing no more 0.02% of water and, if desired, converting the thus-obtained 2-bromo-.alpha.-ergocryptine to an acid addition salt in a known manner.

Process for the preparation of 2-bromo-.alpha.-ergocryptine

The invention relates to pharmaceutical compositions with a neuroleptic action as well as to a process for preparing these compositions. The active ingredients of the compositions of the invention are 2-halo-6-methyl-9-ergolene derivatives of the formula (I), ##STR1## wherein X represents a chlorine, bromine or iodine atom as well as their acid addition salts. The compositions of the invention contain an effective dose of compound of the general formula (I) or an acid addition salt thereof.

Pharmaceutical compositions with a neuroleptic action and process for

The invention relates to new apovincaminol derivatives of the formula /I/ ##STR1## wherein R.sub.1 is hydrogen, nitro or halogen,

Apovincaminol derivative

A process is disclosed for the preparation of dimeric alkaloids of formula (II) ##STR1## wherein R stands for methyl or formyl, as well as acid addition salts thereof which comprises oxidizing the vinblastine of formula (III) ##STR2## with chromium (VI) oxide or bichromate or chromic acid alcohol ester in an inert solvent, converting the compound of formula (II), wherein R stands for methyl, so obtained to the acid addition salt and optionally further oxidizing the acid addition salt obtained with an oxidizing agent as defined above and optionally converting the compound of formula (II), wherein R stands for formyl, so obtained to the acid addition salt.

Process for the preparation of dimeric alkaloids

The invention relates to new indolo[2,3-g]cyclopent[a]indolizine derivatives of the formulae (II) ##STR1## and/or (III) ##STR2## wherein W is alkoxycarbonyl having from one to four carbon atoms in the alkoxy moiety or cyano,

Indolo[2,3-a]quinolizine and indolo[2,3-g]cyclopent[a]indolizine

The invention relates to new 2-azabicyclo[2.2.2]octane derivatives of the formula (I), ##STR1## wherein A is hydrogen, alkoxycarbonyl having from one to 4 carbon atoms in the alkoxy group, phenylalkoxycarbonyl having from one to 4 carbon atoms in the alkoxy moiety, alkyl having from one to 6 carbon atoms, aralkyl containing from one to 4 carbon atoms in the alkyl moiety or substituted acyl,

2-Azabicyclo(2.2.2)octane derivatives and their use as immunosuppressive

The invention relates to new cytostatic compound, process for their preparation and pharmaceutical compositions containing them. More particularly, there are provided new compounds of the general formula ##STR1## in which R.sup.4 is .beta.-hydroxyl and

N-Desmethyl-N-(allyloxymethyl)-vinblastine and antileukemic and

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Budapest, Hungary

Tibor Keve