Intralase Corporation

Vialase, Inc.

Alcon Lensx, Inc.

Intelligent Surgical Lasers Inc.

University of California

Alcon, Inc.

Amo Development, LLC

Cymer, Inc.

Escalon Medical Corporation

University of Michigan

Alcon Lexsx, Inc.

Tibor Juhasz

Ferenc Raksi

Carlos German Suarez

Ronald Michael Kurtz

Guy Holland

Wesley W Lummis

Manu Sharma

Eric R Mikula

Christopher Horvath

Hadi Srass

Ilya Goldshleger

Peter Goldstein

Jeremy Dong

R Kyle Webb

Mark Wesley Ross

Michael F Brownell

Laszlo Nagy

James V Jester

Laszlo Turi

Richard C Ujazdowski

Herve A Besaucele

Robert G Ozarski

Imre Hegedus

James H Azzola

Gordon Scott Scholler

Virginia Lin

Donald J Brown

Moritz Winkler

Attila Raksi

Joselito T Tambo

Scott A Delong

Scott A DeLong

Alan W Berg

Kyle R Webb

J Randy Alexander

William N Partlo

Igor Vladimirovich Fomenkov

Alexander Igorevich Ershov

Richard L Sandstrom

Palash P Das

Josef F Bille

Richard M Ness

Zsolt Bor

Tom A Watson

Daniel Anthony Rothweil

David S Knowles

Ruben Zadoyan

Gerard A Mourou

Chris Davis

Melvin A Sarayba

Richard Ujazdowski

Samantha Bradford

Eric Mikula

Ron Kurtz

Ronald M Kurtz

Zachary S Sacks

Leszlo I Nagy

Wes Lummis

Dongyui Chai

Dongyul Chai

Roger Steinert

Gagik Jotyan

Guy Vern Holland

A target volume of ocular tissue is treated with a laser having a direction of propagation toward the target volume, where the target volume is characterized by a distal extent, a proximal extent, and a lateral extent. A layer of tissue at an initial depth corresponding to the distal extent of the target volume is initially photodisrupted using a femtosecond laser by scanning the laser in multiple directions defining an initial treatment plane. Tissue at one or more subsequent depths between the distal extent of the target volume and the proximal extent of the target volume is subsequently photodisrupted using a femtosecond laser by moving a focus of the laser in a direction opposite the direction of propagation of the laser and then scanning the laser in multiple directions defining a subsequent treatment plane. Photodisruption is repeated at different subsequent depths until tissue at the proximal extent of the target volume is photodisrupted.

Surgical system procedure for treatment of the trabecular meshwork and Schlemm's canal using a femtosecond laser

A system for creating micro-channels through superficial corneal epithelium, the system including: a femtosecond laser having a pulse energy range of 1 to 20 microjoules (μJ) and a capability of generating a laser beam having a wavelength of 700-1100 nanometers (nm) and a repetition rate of 1 kilohertz to 1 megahertz, a laser delivery system comprising a beam expander, a scanning lens having a numerical aperture (NA) of 0.05 to 0.5 and a focusing objective, and control software that controls the delivery system such that the laser beam is scanned in a pattern. The system is used to noninvasively increase corneal epithelial permeability to therapeutic agents through micron-scale channels created through the corneal epithelium by the system or to induce wound healing in a cornea in a subject following creation of micron-scale channels in the cornea.

Nonlinear optical device for micro-machining of the corneal epithelium

A target volume of ocular tissue of an irido-corneal angle of an eye is treated by moving a focus of a laser through the target volume of ocular tissue, and photodisrupting the target volume of ocular tissue at a plurality of spots as the focus is moved through the target volume of ocular tissue. The focus is moved by transverse scanning the focus between at least one of: a first circumferential boundary and a second circumferential boundary of the target volume of ocular tissue, and a first azimuthal boundary and a second azimuthal boundary of the target volume of ocular tissue, and axial scanning the focus between a distal extent and a proximal extent of the target volume of ocular tissue.

System and method for clearing an obstruction from the path of a surgical laser

A target surface in an eye is located using a dual aiming beam apparatus that transmits a first aiming beam of light and a second aiming beam of light. An optics subsystem receives a laser beam from a laser source, the first aiming beam of light, and the second aiming beam of light, and directs the beams of light to be incident with the target surface and aligns the beams of light such that they intersect at a point corresponding to a focus of the laser beam. An imaging apparatus captures an image of the target surface including a first spot corresponding to the first aiming beam of light and a second spot corresponding to a second aiming beam of light. A separation between the spots indicates that the focus is away from the target surface, while overlapping spots indicate the focus is at or on the target surface.

System and method for locating a surface of ocular tissue for glaucoma surgery based on dual aiming beams

A patient interface for an ophthalmic system can include an attachment portion, configured to attach the patient interface to a distal end of the ophthalmic system; a contact portion, configured to dock the patient interface to an eye; and a contact element, coupled to the contact portion, configured to contact a surface of a cornea of the eye as part of the docking of the patient interface to the eye, and having a central portion with a central radius of curvature Rc and a peripheral portion with a peripheral radius of curvature Rp, wherein Rc is smaller than Rp.

Bi-radial patient interface

A look-up table for use in determining an energy parameter for photodisrupting ocular tissue with a laser is generated by determining a plurality of individual spot size distributions, wherein each of the plurality of individual spot size distributions is based on a different set of simulated data and includes an expected spot size of a laser focus at each of a plurality of locations within a modeled target volume of ocular tissue. The plurality of individual spot size distributions are combined to obtain a final spot size distribution that includes a final expected spot size of the laser focus at the plurality of locations of the focus within the modeled target volume of ocular tissue. An energy value is assigned to the plurality of locations of the focus within the modeled target volume of ocular tissue based on the final expected spot size at that location.

System and method for laser treatment of ocular tissue based on patient biometric data and apparatus and method for determining laser energy based on an anatomical model

A method of imaging and treating ocular tissue of an eye having a cornea, an iris, an anterior chamber, an irido-corneal angle, and a direction of view includes establishing a common optical path through the cornea and the anterior chamber into the irido-corneal angle for each of an optical coherence tomography (OCT) beam and a laser beam, where the common optical path is offset from an optical axis within the direction of view. The method also includes obtaining a circumferential OCT image of the irido-corneal angle, obtaining an azimuthal OCT image of the irido-corneal angle, and determining a treatment pattern for a volume of ocular tissue of the irido-corneal angle based on the circumferential OCT image and the azimuthal OCT image. The method further includes delivering optical energy through the laser beam in accordance with the treatment pattern.

Method, system, and apparatus for imaging and surgical scanning of the irido-corneal angle for laser surgery of glaucoma

A device for visualizing an irido-corneal angle of an eye through a window of a patient interface configured to be placed on the eye includes and optics structure and at least one imaging apparatus. The optics structure is configured to engage with the patient interface to provide a line of sight through the window in the direction of the irido-corneal angle, and to subsequently disengage from the patient interface. The imaging apparatus is associated with the optics structure and aligned with the line of sight to enable capturing an image of the eye including the irido-corneal angle.

Alignment and diagnostic device and methods for imaging and surgery at the irido-corneal angle of the eye

To improve the precision of ophthalmic surgical procedures by reducing corneal wrinkling, a patient interface for an ophthalmic system can include an attachment portion, configured to attach the patient interface to a distal end of the ophthalmic system; a contact portion, configured to dock the patient interface to an eye; and a contact element, coupled to the contact portion, configured to contact a surface of a cornea of the eye as part of the docking of the patient interface to the eye, and having a central portion with a central radius of curvature Rc and a peripheral portion with a peripheral radius of curvature Rp, wherein Rc is smaller than Rp.

A target volume of ocular tissue is treated with a laser having a direction of propagation toward the target volume, where the target volume is characterized by a distal extent, a proximal extent, and a lateral extent. A layer of tissue at an initial depth corresponding to the distal extent of the target volume is initially photodisrupted using a femtosecond laser by scanning the laser in multiple directions defining an initial treatment plane. Tissue at one or more subsequent depths between the distal extent of the target volume and the proximal extent of the target volume is subsequently photodisrupted using a femtosecond laser by moving a focus of the laser in a direction opposite the direction of propagation of the laser and then scanning the laser in multiple directions defining an subsequent treatment plane. Photodisruption is repeated at different subsequent depths until tissue at the proximal extent of the target volume is photodisrupted.

Surgical system and procedure for treatment of the trabecular meshwork and Schlemm's canal using a femtosecond laser

The embodiments include method of nonlinear optical photodynamic therapy of tissue including the steps of providing pulsed infrared laser light for two-photon excited fluorescence tissue exposure, and selectively focusing the pulsed infrared laser light within the tissue at a focal plane to activate a photosensitizing agent to generate free radicals within a highly resolved axial and lateral spatial domain in the tissue. The invention is also directed to an apparatus for performing nonlinear optical photodynamic therapy of tissue including a pulsed infrared laser for providing two-photon excited fluorescence beam tissue exposure, a scanner for selectively and controllably moving the tissue and the beam relative to each other, and optics for selectively focusing the pulsed infrared laser light within the tissue at a point in a focal plane to activate a photosensitizing agent to generate free radicals within a highly resolved axial and lateral spatial domain in the tissue.

Nonlinear optical photodynamic therapy (NLO-PDT) of the cornea

Growing community of inventors

Irvine, CA, United States of America

Tibor Juhasz