Richter Gedeon Vegyeszeti Gyar Rt

Tibor Cs

Csaba Szantay

Tibor Keve

Lajos Szabo

Katalin Honty

Gyorgy Fekete

Sandor Eckhardt

Janos Sugar

Laszlo Szporny

Gyorgy Hajos

Sandor Gorog

Elemer Ezer

Lajos Dancsi

Gabor Megyeri

Eszter Dezseri

Zsuzsa Kneffel

Eva Ivan

Sandor Kerpel-Fronius

Hedvig Bolcskei

Zsuzsa Somfai

Ivan Hindi

Zsuzsanna Relle Nee Somfa

The invention relates to novel nitro derivatives of the general formula (I) ##STR1## wherein R.sub.1 stands for a methyl or a formyl group;

Nitro derivatives of vinblastine-type bisindoles, and pharmaceutical

A process is disclosed for the preparation of dimeric alkaloids of formula (II) ##STR1## wherein R stands for methyl or formyl, as well as acid addition salts thereof which comprises oxidizing the vinblastine of formula (III) ##STR2## with chromium (VI) oxide or bichromate or chromic acid alcohol ester in an inert solvent, converting the compound of formula (II), wherein R stands for methyl, so obtained to the acid addition salt and optionally further oxidizing the acid addition salt obtained with an oxidizing agent as defined above and optionally converting the compound of formula (II), wherein R stands for formyl, so obtained to the acid addition salt.

Process for the preparation of dimeric alkaloids

The invention relates to new indolo[2,3-g]cyclopent[a]indolizine derivatives of the formulae (II) ##STR1## and/or (III) ##STR2## wherein W is alkoxycarbonyl having from one to four carbon atoms in the alkoxy moiety or cyano,

Indolo[2,3-a]quinolizine and indolo[2,3-g]cyclopent[a]indolizine

The invention relates to new cytostatic compound, process for their preparation and pharmaceutical compositions containing them. More particularly, there are provided new compounds of the general formula ##STR1## in which R.sup.4 is .beta.-hydroxyl and

N-Desmethyl-N-(allyloxymethyl)-vinblastine and antileukemic and

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Budapest, Hungary

Tibor Cs