General Electric Company

Momentive Performance Materials Gmbh

Tiberiu Mircea Siclovan

Daniel Joseph Brunelle

Joseph Anthony Suriano

James Edward Pickett

Cristina Abucay Tan Hehir

Gregory Allen O'Neil

Victoria Eugenia Cotero

Kenneth Michael Fish

Paul Dean Sybert

Jimmy Lynn Webb

Michael Christopher Montalto

Taeseok Jang

Bruce Fletcher Johnson

Rong Zhang

Randall Lee Carter

Cristina Tan Hehir

Nicole Evelyn Barnhardt

Sterling B Brown

Daniel R Olson

Bret Ja Chisholm

John V Frangioni

Hongyi Zhou

Dennis Joseph Coyle

Grant Hay

Margaret Louise Blohm

Anita Witossek

Sandeep Naik

Donald Joseph Buckley

Stephen Johnson Lomnes

Zhaohui Su

Tunchiao Hubert Lam

Anshika Bajaj

Meenal Mehra

Christian Maria Emile Bailly

James Alan Resue

Chris Anthony Molaison

Amy Casey Williams

Johannes Hepperle

Arindam Sannigrahi

Carrie S Vooght

Kwanho Chang

Debarshi Dasgupta

Georgia Dris Fishburn

Tun Chiao Hubert Lam

Verena Crämer

A process for producing a silicone pressure sensitive adhesive is shown and described herein. The process comprises reacting a MQ silicone resin with a polydiorganosiloxane in the absence of a solvent. The MQ silicone resin is a solid, solventless MQ resin. The reaction may be conducted in the presence of a catalyst, a chain extension reagent, or a combination thereof, and the resulting pressure sensitive adhesive can be dissolved in a solvent and the solids content adjusted. The present method provides a manner to provide a cleaner adhesive material that is free of unwanted materials such as aromatic solvents and also substantially free of cyclic siloxane impurities.

Silicone pressure sensitive adhesive and method of making the same

The present invention relates to a topical agent that binds specifically to myelin basic protein and its method of use and determining myelination in the subject by detecting the agent present in the subject. A kit containing the agent or its derivatives for use in detecting myelin basic protein is also provided.

Topical application of nerve labeling dyes for image-guided surgery

A method and a kit for detecting myelin basic protein are provided. The method comprises administering an agent, which binds to myelin basic protein (MBP), to a subject at risk of or diagnosed with a myelin-associated neuropathy, and determining myelination by detecting the agent resided in the subject. The amount of the agent present in the subject is indicative of a myelin-associated neuropathy. A method of quantifying an amount of MBP present in a tissue sample is also provided, wherein the method comprises contacting the tissue sample with the same agent, detecting the agent present in the tissue sample; and quantifying an amount of the agent present in the tissue sample.

Methods of detecting myelin basic protein

The present invention relates to agents capable of binding to myelin basic protein in a subject. Also provided are methods for the detection of myelin-associated neuropathy comprising identifying a subject at risk of or diagnosed with a myelin-associated neuropathy, administering to a subject an agent that binds specifically to myelin basic protein, and determining myelination in the subject by detecting the agent present in the subject. A kit containing the agent or its derivatives for use in detecting myelin basic protein is also provided.

Agents and methods for the imaging of myelin basic protein

The present invention relates to methods for myelin basic protein detection comprises identifying a subject at risk of or diagnosed with a myelin-associated neuropathy, parenterally administering to the subject the agent, and determining myelination in the subject by detecting binding to myelin basic protein. Methods for the detection of myelin and a quantitative measurement of its local concentration in a sample using an agent with specific binding to myelin basic protein are also provided as is a kit containing the agent or its derivatives for use in detecting myelin basic protein.

Imaging of myelin basic protein

The present invention relates to methods for imaging annulus fibrosus tissue and a quantitative measurement of its local concentration in a sample using an agent comprising the compound of Formula I, aC orH enriched compound of Formula I, anF-labeled derivative of Formula I, a metal-DOTA (1,4,7,10-tetra-azacyclododecane-N,N',N&#x2033;,N&#x2032;&#x2033;-tetraacetic acid) complex of Formula I, or a radioisotope derivative of Formula I.

Annulus fibrosus detection in intervertebral discs using molecular imaging agents

The present invention relates to methods for the detection of myelin and a quantitative measurement of its local concentration in a sample using a benzofuran compound or its radioisotope derivatives. In one embodiment a method of myelin detection comprises identifying a subject at risk of or diagnosed with a myelin-associated neuropathy, parenterally administering to the subject the benzofuran compound, or a derivative of the compound, and determining myelination in the subject by detecting binding in the sample. In one embodiment, the invention provides a method of imaging myelinated tissue in a surgical field of mammalian tissue comprising the steps of contacting the surgical site with the benzofuran compound or a radioisotope derivative of the compound, and detecting binding in the surgical site. In yet another embodiment, a method of imaging spinal cord and spinal nerve root tissue is provided comprising the steps of parenteral administration of a radioisotope derivative of the benzofuran compound and detecting the radioisotope derivative within the spinal canal and intervertebral foramen. Methods of quantification of binding of the benzofuran compound or its derivatives are also provided.

Myelin detection using benzofuran derivatives

Provided herein are agents that bind to soluble beta-amyloid. Also provided are in vivo and in vitro methods for detecting soluble beta-amyloid in a sample that may include brain tissue.

Methods for imaging soluble A-beta

Agents for imaging soluble a-beta

The present invention describes the incorporation of several types of soft-block materials into resorcinol phthalate-co-polycarbonate polymers. In preferred embodiments, the soft-block materials contain aliphatic moieties or silicones as flexibilizing units. Several methods of incorporation into the copolymer structure are described including co-reaction of diols with iso/terephthaloyl chloride, replacement of the normal chainstopper with a p-alkylphenol, replacement of a portion of the bisphenol A with an aliphatic ester-bisphenol, and co-reaction of aliphatic diacid chlorides. The polymers of the present invention have good flow characteristics at temperatures generally used for coating, and have good thermostability and weatherability.

Weatherable, thermostable polymers having improved flow composition

Blends of monofunctional and multifunctional (meth)acrylate monomers, optionally in addition to oligomeric multifunctional (meth)acrylates), can be cured by ultraviolet radiation in contact with a photoinitiator to produce optical resinous articles having a glass transition temperature of at least 35&deg; C. and having physical properties making them suitable for use as microstructure-bearing articles.

Radiation curable microstructure-bearing articles

The present invention provides polycarbonate copolymers having improved hydrolytic stability, solvent resistance, or combinations thereof. In particular, certain of the copolymers of the invention have improved resistance to dilute caustic solution. Thus, the copolymers of the present invention are particularly useful as structural elements in applications where such elements routinely come in contact with caustic solutions, such as in automatic dishwashing equipment. Preferred comonomers include 4,4&prime;-biphenol, bis-(4-hydroxyphenyl)terephthalamide (&ldquo;BHPT&rdquo;), and a bisimide bisphenol obtained by reacting Bisphenol A dianhydride (BPADA) with 4,4&prime;-isopropylidene phenol aniline. The comonomers are utilized along with 2,2-bis(4-hydroxyphenyl)propane (Bisphenol A) in concentrations in a range between about 1 and about 50 weight percent of the repeating units in the polycarbonate.

Polycarbonate copolymers having improved hydrolytic stability

Thermally stable polymers comprising resorcinol arylate chain members are prepared using an interfacial method comprising the steps of: interfacial method for preparing polymers comprising resorcinol arylate polyester chain members substantially free of anhydride linkages linking at least two mers of the polymer chain, comprising the steps of: (a) preparing an aqueous solution comprising at least one resorcinol moiety, said solution having a pH less than or equal to about 5; (b) after step (a), preparing a mixture comprising the resorcinol moiety, at least one catalyst and at least one organic solvent substantially immiscible with water; and (c) adding to the mixture from (b) at least one dicarboxylic acid dichloride while maintaining the pH between 3 and 8.5 through the presence of an acid acceptor, wherein the total molar amount of acid chloride groups is stoichiometrically deficient relative to the total molar amount of phenolic groups.

Thermally stable polymers, method of preparation, and articles made therefrom

Block copolyestercarbonates may be prepared by first conducting a reaction between at least one of resorcinol or an alkyl- or haloresorcinol and at least one aromatic dicarboxylic acid dichloride, preferably isophthaloyl dichloride, terephthaloyl dichloride or a mixture thereof, to produce a hydroxy-terminated polyester intermediate, and then conducting a reaction of the intermediate with a carbonate precursor, preferably in the presence of a dihydroxy compound such as bisphenol A. The products have excellent physical properties, including a high degree of weatherability. They may be blended with other polymers such as polycarbonates, poly(alkylene carboxylates), polyarylates, polyetherimides, and addition polymers to improve the weatherability thereof.

Weatherable block copolyestercarbonates and blends containing them, and method

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Rexford, NY, United States of America

Tiberiu Mircea Siclovan