Ascentage Pharma (Suzhou) Co., Ltd.

Ascentage Pharma Group Corp Limited

Guangzhou Healthquest Pharma Co., Ltd.

Ascentage Pharma Goup Corp Limited

Ascentage Pharma Co., Ltd.

Tianzhu Wu

Jianfeng Wen

Ming Guo

Jianpeng Feng

Huirong Lu

Feng Xu

Yanqiong Lin

Weidong Li

Shangjun Teng

The present invention provides crystalline forms or amorphous forms of N-(phenylsulfonyl) benzoamide compound or its salts or solvates used as a Bcl-2 inhibitor, and the preparation method and the application thereof.

Crystalline forms or amorphous forms of N-(phenyl sulfonyl) benzamide compounds or its salts or solvates

Disclosed herein are a process for preparing alkynyl-containing compound and intermediate thereof. In particular, the present invention discloses a process for preparing a compound of formula 6 as shown in below and a pharmaceutical composition comprising a compound of formula 6 for treating cancer,

Process for preparing alkynyl-containing compound and intermediate thereof

Disclosed is a method for preparing 2-indolinospirone compound and intermediate thereof, specifically disclosed is a method for preparing a compound of formula 5. The method is relatively simple and has high stereoselectivity and yield.

Method for preparing 2-indolinospirone compound and intermediate thereof

The present invention relates to a method for preparing sulfonamides which are inhibitors of Bcl-2/Bcl-xL, comprising the compound (3R)-1-(3-(4-(4-(4-(3-(2-(4-chlorophenyl)-1-isopropyl-4-methylsulfonyl-5-methyl-1H-pyrrol-3-yl)-5-fluorophenyl)piperazin-1-yl)-phenylaminosulfonyl)-2-trifluoro methylsulfonyl-anilino)-4-phenylthio-butyl)-4-hydroxyl-piperidine, and the present invention also relates to intermediates for the preparation of the sulfonamides, a new final product and its therapeutic use, and pharmaceutical use.

Method for preparing sulfonamides drugs

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Suzhou, China

Tianzhu Wu