Harvard College

Tianyang Ye

Hongkun Park

Donhee Ham

Jeffrey T Abbott

Wenxuan Wu

Han Sae Jung

Marsela Jorgolli

Keith Krenek

Ling Qin

Disclosed herein are an apparatus for electrically assessing and/or manipulating cells. One aspect is directed to electrically mapping cells on the surface of the semiconductor substrate via cross-electrode impedance measurements. Further according to some aspects, the electrode array allows for spatially addressable electrical stimulation and/or recording of electrical signals in real-time using the CMOS circuitry. Some of these aspects are directed to using an electrode array to perform cell patterning through electrochemical gas generation, and extracellular electrochemical mapping.

Systems and methods for patterning and spatial electrochemical mapping of cells

Methods and systems for monitoring the activity of electrogenic networks are described. One representative system includes an array of electrode coupled to an analyzer having a stimulator and a receiver. The electrode is placed in contact with an electrogenic cell. The electrodes can be shaped as nanowires, tubes, cavities and/or cones. The analyzer may be configured to operate in a voltage stimulation mode, in which the cells are stimulated via voltages and monitored via current, or in a current stimulation mode, in which the cells are stimulated via currents and monitored via voltages. The analyzers may be arranged as single-stage amplifiers, and may include a feedback loop shared between the stimulation signal path and the sensing signal path. The feedback loop may be arranged to provide overlapping stimulation and sensing of the electrogenic network's cells.

Electronic circuits for analyzing electrogenic cells and related methods

The present invention generally relates to nanowires. In one aspect, the present invention is generally directed to systems and methods of individually addressing nanowires on a surface, e.g., that are substantially upstanding or vertically-oriented with respect to the surface. In some cases, one or more nanowires may be individually addressed using various integrated circuit ('IC') technologies, such as CMOS. For example, the nanowires may form an array on top of an active CMOs integrated circuit.

Integrated circuits for neurotechnology and other applications

Apparatuses for cell mapping via impedance measurements and methods to operate the same

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Cambridge, MA, United States of America

Tianyang Ye