Chinese Academy of Sciences

Shanghai Jiao Tong University

Tiantian Chen

Wei Tang

Hong Tao Liu

Hualiang Jiang

Kaixian Chen

Xu Han

Xiaofen Sun

Kexuan Tang

Fenghua Zhu

Heng Li

Yechun Xu

Guangyu Dong

Wuyan Chen

Xianglei Zhang

Zhanni Gu

Chunlan Feng

Hongmei Qian

Qifang Pan

Hang Liu

Xueqing Fu

Jingya Zhao

Hong Liu

Disclosed are a novel tetrahydroisoquinoline compound, a method for preparing intermediates thereof, a pharmaceutical composition thereof and the use thereof. The tetrahydroisoquinoline compound of the present invention has a good inhibitory effect on phosphodiesterase (PDE4), and can be used in the prevention, treatment or auxiliary treatment of multiple diseases associated with the activity or expression of phosphodiesterase, especially PDE4-associated immune and inflammatory diseases, such as psoriasis and arthritis.

Tetrahydroisoquinoline compound, preparation method therefor, pharmaceutical composition containing same, and use thereof

A gene RNAi vector is constructed with a V-ATPase subunit E gene fragment, a COO2 gene fragment, or a combination of the V-ATPase subunit E gene fragment and the COO2 gene fragment, then transferred into a plant, and expressed in the plant to produce dsRNA of the V-ATPase subunit E gene, the COO2 gene, or the combination of the V-ATPase subunit E gene and the COO2 double gene, and therefore the aphid growth is suppressed, and the plant is enhanced in pest resistance.

Nucleotide sequence and application thereof in enhancing plant pest resistance

Growing community of inventors

Shanghai, China

Tiantian Chen