Amgen Inc.

Kirin-Amgen, Inc.

Tiansheng Li

Christopher James Sloey

Jason Ko

Camille Vergara

Karthik Nagapudi

Merrill Seymour Goldenberg

Alice C Beekman

Daxian Shan

Grace C Chu

Zhuohong Huang

Mariko Aoki

Alexis Lueras

Byeong S Chang

Camille Gleason

Rahul Rajan

Christopher Sloey

The present invention relates to stable aqueous protein formulations. In particular, disclosed herein are therapeutic protein formulations suitable for parenteral administration having one or more antioxidants.

Aqueous antibody formulation stabilized by antioxidants for parenteral administration

Aqueous formulation of erythropoiesis stimulating protein stabilised by antioxidants for parenteral administration

A method of stabilizing an aqueous protein or antibody formulation is disclosed herein. Additionally, stable pharmaceutical formulations are contemplated which comprise a biologically active protein, a destabilizing concentration of preservative and a stabilizing concentration of osmolyte.

Pharmaceutical formulations

A stable pharmaceutical formulation is provided that comprises a biologically active protein and an excipient selected from carnitine, creatine or creatinine.

Compositions comprising nonpolar amino acids and specific binding agents to hepatocyte growth factor (HGF) are provided. Methods of making and using such compositions are also provided.

Compositions of specific binding agents to hepatocyte growth factor

The present invention relates to the preparation of polyol/thickened oil suspensions containing a biologically active agent, for the sustained delivery of the biologically active agent. The described protein/glycerol/oil suspensions show sustained release of protein, e.g., G-CSF, of up to at least one week.

Polyol/oil suspensions for the sustained release of proteins

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Newbury Park, CA, United States of America

Tiansheng Li