Zhejiang Huahai Pharmaceutical Co., Ltd.

Tianpei Huang

Min Li

Jinsheng Lin

Wenquan Zhu

Zhiyun Wang

Dan Li

Libin Hu

Qiang Zhou

Tong Wu

Hong Cai

Wenbin Chen

Xiaoyan Xu

Tan Xiao

Danfeng Ye

Feifei Lan

Disclosed is N-formyl vortioxetine, and also disclosed is a method for preparing the N-formyl vortioxetine and a stable solid preparation of vortioxetine.

N-formyl vortioxetine and preparation method thereof and solid preparation of vortioxetine

Disclosed is a detection method for N-nitrosodimethylamine (NDMA) impurities, comprising: (1) obtaining a test solution containing a sample to be tested; and (2) detecting the test solution by means of gas chromatography-mass spectrometry to determine the content of an N-nitrosodimethylamine impurity in the sample. The method provided in the present invention has a good separating effect, a wide linear range, a high sensitivity and a good method durability, and can detect the content of N-nitrosodimethylamine (NDMA) in the sample rapidly and effectively.

Detection method for n-nitrosodimethylamine impurities

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Zhejiang, China

Tianpei Huang