Peking University

Beijing Qiyi Century Science & Technology Co., Ltd.

Tianchang Wang

Jun Hu

Qi Yang

Qing Xia

Yingjie Chen

Chengcan Ye

The present application provides an error correction method and device for search terms. The method comprises: identifying an incorrect search term; calculating weighted edit distances between the search term and pre-obtained hot terms by using a weighted edit distance algorithm, wherein, during the calculation of the weighted edit distances, different weights are set respectively for the following operations of transforming from the search term to the hot terms: an operation of inserting characters, an operation of deleting characters, an operation of replacing by characters with similar appearance or pronunciation, an operation of replacing by characters with dissimilar appearance or pronunciation, and an operation of exchanging characters; and selecting a predetermined number of hot terms based on the weighted edit distances and popularity of the hot terms for error correction prompt. The method and device of the present application can improve the error correction accuracy of error search terms.

Error correction method and device for search term

Provided are a method for constructing a suppressor tRNA, and 19 suppressor tRNAs corresponding to three termination codons, a plasmid, a vector or a kit comprising the above-mentioned tRNA. Also provided are use of the above-mentioned tRNA, plasmid, vector or kit in the manufacture of a medicament for treating a hereditary disease or a cancer caused by a nonsense mutation of a gene. Also provided are a method for evaluating the efficiency of a suppressor tRNA for reading through a nonsense mutation, and a method for restoring the expression of a truncated protein of a nonsense mutant of a pathogenic gene in a monogenic hereditary disease and a tumor suppressor gene in a tumor cell.

Read through of truncated proteins in premature termination codon diseases by suppressor tRNAs

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Beijing, China

Tianchang Wang