United States of America As Represented by the Administrator of Nasa

Thuc Phan

Shahid Aslam

George Nehmetallah

Imaging devices, methods, and systems are disclosed. The disclosure includes a Fourier Ptychographic Microscope ('FPM') compatible for integration to a Microfluidic Device (“MD”) to perform wide Field-of-View (“FoV”), high spatial resolution imaging (<1 μm), for biosignature detection and motility in liquid samples, for use, without limitation, as a space-based payload. Fourier ptychography (“FP”) algorithms adapted for reconstruction are disclosed. A processor board and camera combined with FP algorithms adapted for reconstruction are used to computationally reconstruct sub-micron resolution images. In certain embodiments, a dual-modality portable FPM performs wide FoV, high lateral and axial resolution imaging, and high-resolution birefringence imaging, for biosignature detection and motility in liquid samples. Various combinations of the disclosed devices, methods, and systems may be employed, depending on the particular requirements of each implementation.

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Thuc Phan