Council of Scientific and Industrial Research

Thottappillil Ravindranathan

Subhash Prataprao Chavan

Uttam Ramrao Kalkote

Sandeep Raghunath Ghorpade

Sunil Ramchandra Bhide

Pradeep Kumar

Arumugamangalam Venkataraman Ramaswamy

Alive Keshavaraja

Sooryakant Ganesh Hegde

Vishnumurthy Ramachandra Hegde

The present invention relates to a process for the preparation of optically active 6-hydroxymethyl-4-(tert-butyldimethylsilyloxy)-(4R,6S)-tetrahydro-2H-2-pyranone(&bgr;-Hydroxy-&dgr;-lactone) an important intermediate in the synthesis of biologically active drugs e.g. compactin, atorvastatin, fluvastatin, cholesterol lowering drugs.

Process for the preparation of beta hydroxy-delta lactone using novel intermediates

Process for the preparation of &bgr; hydroxy-&dgr; lactone using novel intermediates

A process for the preparation of organic compounds through C--C bond forming reaction which comprises reacting a diene with a dienophile in the presence of solid acid based on either yttrium, scandium or lanthanum supported on metal oxide supports such as oxides of zirconium or tin or titanium or iron oxide modified by sulphation as catalysts for a period ranging from 5 to 48 hours and recovering the reaction products from the reaction mixture by filtration and removal of the solvent by evaporation followed by column chromatography.

Process for the C-C bond forming reaction using solid acid catalysts

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Maharashtra, India

Thottappillil Ravindranathan