Emory University

Virginia Tech Intellectual Properties Inc

Imperial Innovations Limited

Binghamton University

Imperial College Innovations Limited

Thota Ganesh

Jianxiong Jiang

Aiming Sun

Ray J Dingledine

John David Lambeth

Raymond J Dingledine

Yuhong Du

Pahk Thepchatri

Yi Quan

Susan M Smith

James P Snyder

Robert Albert Brown

Matthew John Fuchter

Jin Liu

David George Ian Kingston

James Patrick Synder

Ami S Lakdawala

Nadine Chapman-Rothe

Susan Lynn Bane

Radhika Amaradahi

Nitipol Srimongkolpithak

Shabber Mohammed

Joachim Caron

Susane M Smith

Robert Brown

The disclosure relates to Prostnglandin receptor EP2 antagonists, derivatives, compositions, and methods related thereto. In certain embodiments, the disclosure relates to methods of treating or preventing conditions and diseases in which EP2 receptor activation has a physiological role, such as but not limited to, brain injury, inflammatory diseases, epilepsy, neuroinflammation after a seizure, pain, endometriosis, cancer, rheumatoid arthritis, skin inflammation, vascular inflammation, colitis, and neurological disorders by administering a pharmaceutical composition comprising a compound disclosed herein to a subject in need thereof.

Prostaglandin receptor EP2 antagonists, derivatives, and uses related thereto

The disclosure relates to Prostaglandin receptor EP2 antagonists, derivatives, compositions, and methods related thereto. In certain embodiments, the disclosure relates to methods of treating or preventing conditions and diseases in which EP2 receptor activation has a physiological role, such as but not limited to, brain injury, inflammatory diseases, neuroinflammation after a seizure, pain, endometriosis, cancer, rheumatoid arthritis, skin inflammation, vascular inflammation, colitis, and neurological disorders by administering a pharmaceutical composition comprising a compound disclosed herein to a subject in need thereof.

Prostaglandin receptor EP2 antagonists, derivatives, compositions, and uses related thereto

The disclosure relates to Prostaglandin receptor EP2 antagonists, derivatives, compositions, and methods related thereto. In certain embodiments, the disclosure relates to methods of treating or preventing conditions and diseases in which EP2 receptor activation has a physiological role, such as but not limited to, brain injury, inflammatory diseases, neuroinflamation after a seizure, pain, endometriosis, cancer, rheumatoid arthritis, skin inflammation, vascular inflammation, colitis, and neurological disorders by administering a pharmaceutical composition comprising a compound disclosed herein to a subject in need thereof.

The disclosure relates to quinazoline derivatives, compositions, and methods related thereto. In certain embodiments, the disclosure relates to inhibitors of NADPH-oxidases (Nox enzymes) and/or myeloperoxidase.

Quinazoline derivatives, compositions, and uses related thereto

This invention relates to quinazoline compounds of Formula (I) which are inhibitors of the histone lysine methyltransferase (HKMTase) EZH2, and to uses of such compounds as medicaments, in particular in the treatment of a disease or disorder in which inhibition of EZH2 provides a therapeutic or prophylactic effect. 

Quinazoline compounds and their use in therapy

The invention relates to quinazoline derivatives, compositions, and methods related thereto. In certain embodiments, the invention relates to inhibitors of NADPH-oxidase.

The present invention is directed to compounds of Formula IC: 

The disclosure relates to piperazine derivatives, compositions, and methods related thereto. In certain embodiments, the disclosure relates to inhibitors of NADPH-oxidase.

Piperazine derivatives, compositions, and uses related thereto

Constrained paclitaxel derivatives include a bridge extending from the C-3' phenyl to either the C4 or -3 positions. Many of the constrained paclitaxel derivatives provide activity comparable or superior to the natural product paclitaxel.

Conformationally constrained paclitaxel analogs and their use as anticancer and anti-Alzheimers agents

Growing community of inventors

Alpharetta, GA, United States of America

Thota Ganesh