Sandoz Ag

Thorsten Wilhelm

Martin Langner

Hubert Sturm

Dominic De Souza

Martin Albert

Wolfgang Felzmann

Joerg Salchenegger

Michael Oberhuber

Olga Schöne

Kathrin Hoeferl-Prantz

Hans-Peter Spitzenstaetter

David Benito-Garagorri

Jörg Salchenegger

Hans-Peter SPITZENSTÄTTER

A process for preparing a compound of formula (I) or a salt thereof, the process comprising providing a compound of formula (III) wherein PG is an inert electron withdrawing hydroxyl protecting group, reacting the compound of formula (III) with a fluorinating agent, obtaining a compound of formula (II) and deprotecting the compound of formula (II). 

Synthesis of phosphoramidates

The present invention relates to a process for the preparation of a compound of formula (V), in particular posaconazole, wherein said process comprises the steps of (1) providing a mixture comprising a compound of formula (IV), a protic solvent system, and a suitable base; and (2) heating the mixture of (1) to obtain a mixture comprising the compound of formula (V). 

Process for the preparation of a chiral compound

The invention relates to synthetic routes for preparing telaprevir and boceprevir, and its intermediates as well as peptides other than telaprevir. The synthetic routes are based on a Mukaiyama aldol addition reaction of a silyl enol ether or an enolate with an imine. The invention also refers to novel intermediates for preparing telaprevir/boceprevir or other peptides.

Synthesis of telaprevir and boceprevir, or pharmaceutically acceptable salts or solvates as well as intermediate products thereof including &#x3b2;-amino acids prepared via Mukaiyama aldol addition

A process for the preparation of a chiral compound, in particular posaconazole, wherein the process comprises mixing and reacting the compounds of formula (I) Y&#x2014;NH; of formula (IIa) 0=C&#x2550;N&#x2014;Yand/or of formula (IIb) and of formula (III) in a solvent in any order to obtain a reaction mixture containing a chiral compound of formula (IV) and/or formula (V). 

Process for the preparation of chiral triazolones

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Kundl, Austria

Thorsten Wilhelm