Université´ D'aix-marseille

Bridge12 Technologies, Inc.

Massachusetts Institute of Technology

Thorsten Maly

Paul Tordo

Yoh Matsuki

Robert G Griffin

Francois Le Moigne

Hakim Karoui

Olivier Ouari

Oliver Ouari

Jagadishwar R Sirigiri

François Le Moigne

The present invention relates to the field of organic chemistry and in particular to organic free radicals used as polarizing agents in the technique of Dynamic Nuclear Polarization (DNP), which involves transferring the polarization of electron spins to the nuclei of a compound whose Nuclear Magnetic Resonance (NMR) is being observed. It concerns Dinitroxide-type Biradical polarizing agents characterized by a rigid linkage between the aminoxyl groups of said nitroxide units. This particular structure enables, at low temperatures and high fields, optimal transfer of polarization and optimal enhancement of NMR/MAS signals of the polarized nuclei of the compound studied.

Dinitroxide-type biradical compounds optimized for dynamic nuclear polarization (DNP)

An integrated high-frequency generator system utilizing the magnetic field of the target application including a magnetic resonance magnet having an application zone and a high-frequency (microwave/terahertz) generator zone in the magnetic field of the magnetic resonance magnet; and a high-frequency (microwave/terahertz) generator disposed in the high-frequency (microwave/terahertz) generator zone and utilizing the magnet field of the magnetic resonance magnet to generate the high-frequency (microwave/terahertz) radiation. The magnetic resonance magnet may have an auxiliary magnetic field source for modifying the magnetic field profile in the high-frequency (microwave/terahertz) generator zone. The high-frequency (microwave/terahertz) generator may include an electron gun for generating an electron beam adapted to be focused by a magnetic field source having a spatially rising region, a homogenous region and a decaying region, an interaction structure for generating high-frequency (microwave/terahertz) radiation, an internal mode converter in the homogenous region for extracting the high-frequency (microwave/terahertz) radiation through a window, and a reduced collector disposed substantially in the homogenous region before the electron beam spreads in the decaying region.

Integrated high-frequency generator system utilizing the magnetic field of the target application

The present invention relates to the field of organic chemistry and in particular to organic free radicals used as polarizing agents in the technique of Dynamic Nuclear Polarization (DNP), which involves transferring the polarization of electron spins to the nuclei of a compound whose Nuclear Magnetic Resonance (NMR) is being observed. It concerns dinitroxide-type biradical polarizing agents characterized by a rigid linkage between the nitroxide units that enables optimal orientation and distance to be maintained between the aminoxyl groups of said nitroxide units. This particular structure enables, at low temperatures and high fields, optimal transfer of polarization and optimal enhancement of NMR/MAS signals of the polarized nuclei of the compound studied.

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Somerville, MA, United States of America

Thorsten Maly