Nycomed Imaging As

Daiichi Pharmaceutical Co., Ltd.

Santosolve As

Thorfinn Ege

Jo Klaveness

Scott M Rocklage

Hiroshi Kikuchi

Arne Berg

Pal Rongved

Kiyoto Yachi

Clas Magne Kjølberg

Egil Jellum

Bjørn Jarl Fagerlund

Trond Vegard Jacobsen

Clas Magne Kjolberg

Bjorn Jarl Fagerlund

The present invention relates to the use of paramagnetic materials, such as lanthanide chelates, as contrast agents in magnetometric analysis, especially imaging. The invention is particularly directed to structural and functional diagnosis or imaging.

Lanthanide paramagnetic agents for magnetometric imaging

The invention provides for the use of a physiologically tolerable, particulate, free or matrix-borne, ferromagnetic, ferrimagnetic or paramagnetic material for the manufacture of a diagnostic agent for magnetometric imaging of a human or non-human animal body.

SQUID magnetometry using ferro-, ferri- are paramagnetic particles

The invention provides a diagnostic composition for administration to human or animal subjects, the composition containing multilamellar liposomes, optionally together with unilamellar liposomes, the liposomes containing at least one imaging agent and being suspended in an aqueous medium containing said imaging agent, wherein the liposomes comprise a neutral phospholipid and a charged phospholipid, the average particle diameter of the liposomes is 50-3000 nm and the concentration of imaging agent in any aqueous phase filling the interior of the liposomes is substantially the same as that in the aqueous medium in which the liposomes are suspended. The contrast agents concerned are typically X-ray, MRI or ultrasound contrast agents.

Liposomes

Squid magnetometry using paramagnetic metal chelates

Squid magnetometry using ferri-and ferromagnetic particles

Diagnostic magnetometry using superparamagnetic particles

Growing community of inventors

Oslo, Norway

Thorfinn Ege