Adama Makhteshim, Ltd.

Thomas Zell

Shlomi Cohen

Jie Li

Itsik Bar-Nahum

Boris Rubinov

Avihai Yacovan

A method is disclosed for preparing pyrazole derivative 3-bromo-5-methyl-1-H-pyrazole-N-2-chloropyridine (compound of Formula I) by reacting of a compound of Formula II with halogen substituted pyridine optionally in the presence of base and organic solvent or by decarboxylation of pyrazole carboxylic acid of Formula XI in the presence of acid. In addition, provided a method of preparation of synthetic precursors of Formula II, Formula IV, Formula V, Formula VI, Formula XI, and a method of preparing a compound of Formula VII comprising reacting a compound of Formula I with an oxidant optionally in the presence of a catalyst. Also disclosed a compound of Formula I as useful synthetic precursor for preparation of anthranilamide of Formula VIII.

Preparation of substituted pyrazoles and their use as anthranilamides precursors

The present invention provides a process for preparing a compound of formula [I] from a compound of formula [II] using an oxidizing agent and a catalyst, the process is carried out at a low temperature.

Synthesis of 1,1,2-trifluoro-4-(substituted sufonyl)-but-1-ene

The invention provides a process for preparing heterocyclic fluoroalkenyl sulfones and their thioether and sulfoxide precursors of the formula: Cl&#x2014;R&#x2014;S(O)&#x2014;(CH)&#x2014;CF&#x2550;CF(Formula I') wherein R is a heterocyclic five-membered aromatic ring and n is 0, 1 or 2, comprising a step of dehalogenation of a compound of the formula: Cl&#x2014;R&#x2014;S(O)&#x2014;(CH)&#x2014;CFX&#x2014;CFX(Intermediate B), wherein Xand Xare independently halogen atoms, to remove said Xand Xatoms. Also included are novel intermediate compounds.

Process and intermediates for the preparation of Fluensulfone

The present invention provides an improved process for preparing 5-chloro-2-[(3,4,4-trifluoro-3-buten-1-yl)thio]-thiazole comprising reacting 2-[(3,4,4-trifluoro-3-buten-1-yl)thio]-thiazole with N-chlorosuccinimide (NCS) in the presence of water, the improvement comprising performing the step of reacting the compound of formula (II) with NCS in the presence of a reduced amount of water. The present invention provides an improved process for preparing 5-chloro-2-[(3, 4,4-trifluoro-3-buten-1-yl)thio]-thiazole comprising reacting 2-[(3, 4,4-trifluoro-3-buten-1-yl)thio]-thiazole with N-chlorosuccinimide (NCS) in the presence of water, the improvement comprising performing the step of reacting the compound of formula (II) with an excess molar amount of NCS.

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Beer Sheva, Israel

Thomas Zell